Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington's disease
about
Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS.Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's diseaseDNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases.Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Phosphorylation of histone H2AX in the mouse brain from development to senescence.Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.A BRCA1-Dependent DNA Damage Response in the Regenerating Adult Peripheral Nerve Milieu.DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.
P2860
Q35906462-E59CDCFB-9E98-4E76-8517-6CA748F6CF55Q36276521-082D425A-EB6C-454E-BB13-F77BA5DCEF43Q36361006-91C9A522-42BC-4006-9098-59B1444C62B0Q37249162-4D3EDDB6-25FB-4C63-A787-036F0E1D5C55Q38925490-FE7FFBFF-3602-4254-98C0-C3E0899EAAA8Q38973133-FB6D3645-9424-4D86-B725-3A9B06D3478BQ41902115-905CCBD7-B055-4412-A417-558A531B5EB5Q44666439-40C50277-4CA4-463C-AFB3-1EDB90281A2AQ47702504-78CC58D4-4B5B-4C2B-85A1-FA7A9B50E02AQ51252315-B3E82C34-8198-411E-8B9F-6CD892F59415
P2860
Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington's disease
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@ast
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@en
type
label
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@ast
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@en
prefLabel
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@ast
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@en
P2093
P2860
P1476
Deregulation of BRCA1 leads to ...... ponses in Huntington's disease
@en
P2093
Gye Sun Jeon
Junghee Lee
Ki Yoon Kim
Min-Kyung Jung
Mutsuko Ouchi
Neil Kowall
Sungkwan An
Toru Ouchi
Yu Jin Hwang
P2860
P2888
P304
P356
10.1007/S12035-012-8274-9
P50
P577
2012-05-13T00:00:00Z