Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function. - Wikidata - wikimedia - TriplyDB

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function.

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function.

http://www.wikidata.org/entity/Q36274969

about

Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta Pharmacological manipulation of cell death: clinical applications in sight?Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)XIAP is not required for human tumor cell survival in the absence of an exogenous death signal Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis.Oncogenic activation of NF-kappaB.NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1).Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer XAF1 is frequently methylated in human esophageal cancer IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.Serum Survivin and TP53 Gene Expression in Children with Acute Lymphoblastic Leukemia.The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition.Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.Therapeutic targets in the mitochondrial apoptotic pathway.Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance.X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis.IAPs: what's in a name?Molecules that modulate Apaf-1 activity.Small-molecule pan-IAP antagonists: a patent review.Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways.The impact of hypoxia on cell death pathways.IAPs on the move: role of inhibitors of apoptosis proteins in cell migration.Survivin as a preferential target for cancer therapy.Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene.cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.Diverse functions within the IAP family.Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins.The opposing roles of cellular inhibitor of apoptosis proteins in cancer.The cellular inhibitor of apoptosis protein-2 is a possible target of novel treatment for endometriosis.

P2860

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P2860

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function.

http://www.wikidata.org/entity/Q36274969

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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Reawakening the cellular death ...... utic blockade of IAP function.

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Reawakening the cellular death ...... utic blockade of IAP function.

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Casey W Wright

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Colin S Duckett

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P2860

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

Mechanism of XIAP-mediated inhibition of caspase-9

A novel role for XIAP in copper homeostasis through regulation of MURR1

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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2673-2678

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10.1172/JCI26251

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