A dominant-negative transgene defines a role for p56lck in thymopoiesis.
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p56Lck anchors CD4 to distinct microdomains on microvilli.Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient miceExpression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte developmentMetabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ culturesDeletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell developmentDevelopment of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathwayLck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signalingLckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.c-Myb is essential for early T cell development.The GTPase Rho has a critical regulatory role in thymus development.Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responsesAllelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.Dietary zinc deficiency in rodents: effects on T-cell development, maturation and phenotypesIntestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage.Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4.Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate diseaseThe protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionSelective activation of the calcium signaling pathway by altered peptide ligandsAutonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).Characterization of T cell differentiation in the murine gut.Major T cell progenitor activity in bone marrow-derived spleen colonies.PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice.Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytesLck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitionsReplacement of pre-T cell receptor signaling functions by the CD4 coreceptorMalignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytesTissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation.Functional analysis of histone methyltransferase g9a in B and T lymphocytes.Defective expression of p56lck in an infant with severe combined immunodeficiency.PU.1 regulates TCR expression by modulating GATA-3 activity.Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.
P2860
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P2860
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
description
1993 nî lūn-bûn
@nan
1993 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@ast
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@en
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@nl
type
label
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@ast
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@en
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@nl
prefLabel
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@ast
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@en
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@nl
P2093
P2860
P1433
P1476
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
@en
P2093
K A Forbush
R M Perlmutter
S J Anderson
P2860
P304
P407
P577
1993-04-01T00:00:00Z