Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. - Wikidata - wikimedia - TriplyDB

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.

http://www.wikidata.org/entity/Q35918236

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How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?Immunotherapy in autoimmune type 1 diabetes Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients.Treg vaccination with a strong-agonistic insulin mimetope.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Antigen-based vs. systemic immunomodulation in type 1 diabetes: the pros and cons.Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes.Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.Central and peripheral autoantigen presentation in immune tolerance.Neuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse.Antigen targets of type 1 diabetes autoimmunity Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD mice Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.Immunopathogenesis and immunotherapeutic approaches to type 1A diabetes.Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.The stages of type 1A diabetes: 2005.Islet autoantigens: structure, function, localization, and regulation.Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.Achieving antigen-specific tolerance in diabetes: regulating specifically.The insulin A-chain epitope recognized by human T cells is posttranslationally modified An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Insulin as an autoantigen in NOD/human diabetes Adaptive evolution of the insulin two-gene system in mouse.Extrapancreatic insulin-producing cells in multiple organs in diabetes Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.Conserved T cell receptor alpha-chain induces insulin autoantibodies.Extreme genetic risk for type 1A diabetes in the post-genome era George S. Eisenbarth: insulin and type 1 diabetes.Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes.The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice

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Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.

http://www.wikidata.org/entity/Q35918236

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Proceedings of the National Academy of Sciences of the United States of America

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Devasenan Devendra

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Dongmei Miao

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Edwin Liu

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George S Eisenbarth

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Hiroaki Moriyama

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Johanna Paronen

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Joshua Beilke

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Kamila Sikora

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Norio Abiru

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Roberto Gianani

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P2860

Projection of an immunological self shadow within the thymus by the aire protein

Defining criteria for autoimmune diseases (Witebsky's postulates revisited)

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

T cell response to preproinsulin I and II in the nonobese diabetic mouse.

Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis.

The role of CD4 vs. CD8 T cells in IDDM.

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

Has GAD a central role in type 1 diabetes?

Does GAD have a unique role in triggering IDDM?

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.

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12925730

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