NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.
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Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyreneDisruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancerEffects of redox cycling compounds on DT diaphorase activity in the liver of rainbow trout (Oncorhynchus mykiss)Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyreneVariation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.Benzene, NQO1, and genetic susceptibility to cancer.Breast cancer: role of polymorphisms in biotransformation enzymes.Acute disruption of bone marrow hematopoiesis by benzo(a)pyrene is selectively reversed by aryl hydrocarbon receptor-mediated processes.Selective induction of tumor cell apoptosis by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl) propiolate.Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue.Modulation of glucose-6-phosphate dehydrogenase activity and expression is associated with aryl hydrocarbon resistance in vitro.NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.Proteomic analysis reveals that a global response is induced by subinhibitory concentrations of ampicillin.β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.Oxidative stress and cell-cycle change induced by coexposed PCB126 and benzo(a) pyrene to human hepatoma (HepG2) cells.
P2860
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P2860
NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@ast
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@en
type
label
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@ast
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@en
prefLabel
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@ast
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@en
P2860
P356
P1476
NAD(P)H:quinone oxidoreductase ...... es of benzo(a)pyrene quinones.
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.1998.117
P407
P577
1998-03-01T00:00:00Z