The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.
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Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunitsThe KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityKCNQ1 channel modulation by KCNE proteins via the voltage-sensing domainStructure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitabilityFunctional significance of K+ channel β-subunit KCNE3 in auditory neuronsKCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channelKCNE2 and the K (+) channel: the tail wagging the dogA shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensorIKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunitsGenetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivoKCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gateStoichiometry of the KCNQ1 - KCNE1 ion channel complex.Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.KCNE1 constrains the voltage sensor of Kv7.1 K+ channels.Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes.Studies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4.KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsN-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environmentsGating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channelsKCNE3 acts by promoting voltage sensor activation in KCNQ1.KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains.Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunitVoltage-dependent C-type inactivation in a constitutively open K+ channelKCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing?KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulationStructural basis for KCNE3 modulation of potassium recycling in epitheliaStructural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex.Ion channel-transporter interactions.Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channelVoltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Probing the interaction of the potassium channel modulating KCNE1 in lipid bilayers via solid-state NMR spectroscopy.Molecular Pathophysiology of Congenital Long QT Syndrome.Chansporter complexes in cell signaling.
P2860
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P2860
The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The role of S4 charges in volt ...... 1 potassium channel complexes.
@ast
The role of S4 charges in volt ...... 1 potassium channel complexes.
@en
type
label
The role of S4 charges in volt ...... 1 potassium channel complexes.
@ast
The role of S4 charges in volt ...... 1 potassium channel complexes.
@en
prefLabel
The role of S4 charges in volt ...... 1 potassium channel complexes.
@ast
The role of S4 charges in volt ...... 1 potassium channel complexes.
@en
P2860
P356
P1476
The role of S4 charges in volt ...... 1 potassium channel complexes.
@en
P2093
Gianina Panaghie
P2860
P304
P356
10.1085/JGP.200609612
P577
2007-01-16T00:00:00Z