KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels
about
Intracellular domains interactions and gated motions of I(KS) potassium channel subunitsDynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2The KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityKCNQ1 channel modulation by KCNE proteins via the voltage-sensing domainStructure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡Structural basis of slow activation gating in the cardiac I Ks channel complexIKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunitsKCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gateStoichiometry of the KCNQ1 - KCNE1 ion channel complex.Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel.A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation.KCNE1 constrains the voltage sensor of Kv7.1 K+ channels.Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes.Voltage-dependent gating in a "voltage sensor-less" ion channel.KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsState-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activationKCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.Chemical control of metabolically-engineered voltage-gated K+ channels.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelKCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.Partial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 β-subunitRegulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.KCNE3 acts by promoting voltage sensor activation in KCNQ1.Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.Tethering chemistry and K+ channels.Structural basis for KCNE3 modulation of potassium recycling in epitheliaBuilding KCNQ1/KCNE1 channel models and probing their interactions by molecular-dynamics simulations.Structural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex.The KCNE Tango - How KCNE1 Interacts with Kv7.1.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels.Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening.
P2860
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P2860
KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@ast
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@en
type
label
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@ast
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@en
prefLabel
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@ast
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@en
P2860
P356
P1476
KCNE peptides differently affe ...... ion rates in KCNQ1 K+ channels
@en
P2093
Jessica M Rocheleau
William R Kobertz
P2860
P356
10.1085/JGP.200709816
P577
2007-12-17T00:00:00Z