Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.
about
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyCysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cellsStructure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysisSignaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma CellsA PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1In search of selective P2 receptor ligands: interaction of dihydropyridine derivatives at recombinant rat P2X(2) receptorsRibose modified nucleosides and nucleotides as ligands for purine receptorsStructurally related nucleotides as selective agonists and antagonists at P2Y1 receptorsMolecular recognition at purine and pyrimidine nucleotide (P2) receptors.GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.Inherited platelet-based bleeding disorders.Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis.Pharmacochemistry of the platelet purinergic receptors.Two disparate ligand-binding sites in the human P2Y1 receptor.Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes.Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.Shift in purine/pyrimidine base recognition upon exchanging extracellular domains in P2Y 1/6 chimeric receptors.Molecular recognition at adenine nucleotide (P2) receptors in platelets.4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactionsNucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.Purine receptors: GPCR structure and agonist designThe ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia.P2Y(1) receptor modulation of endogenous ion channel function in Xenopus oocytes: Involvement of transmembrane domains.Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.Evidence for the Recognition of Non-Nucleotide Antagonists Within the Transmembrane Domains of the Human P2Y(1) ReceptorMolecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.Probing GPCR structure: adenosine and P2Y nucleotide receptors.Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.The Molecular Mechanism of P2Y1 Receptor ActivationThe A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.Molecular defects of the platelet P2 receptors.Rare missense mutations in P2RY11 in narcolepsy with cataplexy.Identification of hydrolytically stable and selective P2Y(1) receptor agonists.
P2860
Q24629255-2DBEA014-95BE-4DB6-93A7-5BA52211E65DQ24632991-E2B5948B-E1DC-49C1-9B61-C83597D6C588Q24682069-E80252CD-ED58-4979-8B18-191E3239FD8CQ25255546-C76FD2F0-8F23-4D44-B20B-F97F8F9EFCE5Q28195840-71878AD3-96F8-4917-B856-7262F3C7F296Q28344394-33F7AA3B-4815-47C1-BECC-490D19864F13Q28354391-33AABDE6-6FC6-44CE-A9CC-6139C3AA3399Q28364756-0EAB7307-07E4-43E2-A744-0C332459E475Q33201399-EFEA6F40-2DEF-4618-9E32-86DF5259E245Q33340702-409E95DA-6679-4C43-B2B8-8202E45E13B4Q33349071-CD308A53-14BF-4997-836F-EAA68B472DACQ33541287-0DCCF4D3-7873-4D8B-8F32-6571D15FF34BQ33768388-BDA9D0A6-1E36-468F-A1F2-84DE910BA0F9Q33869922-34CA7941-E8BA-46BB-A1ED-A0EE4391E048Q34469331-C5459653-BF1F-46E9-9F7E-7FA73888E53EQ34612600-849391E6-11A2-411F-824C-D62145C0D99BQ35050462-472709BE-42FB-4A03-A58A-84597059BC90Q35051133-67D0CA28-5CE6-4F84-AD17-C60B89FEF669Q35100653-4763882A-D675-405D-891E-3526C56B918EQ35130686-02C29A8B-0497-43E4-8E21-30319C34A1A9Q35211567-D4F1DD54-683F-4CF2-9FF6-383EAD3F815AQ35580443-ECA9ACFC-C434-4E59-BBB6-B2A37BE9DF24Q35825847-8F9859C2-3E08-4950-9A5A-A74F0AE3FAAFQ35987700-320ED2FA-C90E-4C17-BAFB-B239C6D66543Q36110665-785B9171-1073-4E06-9302-6D5D329D6752Q36161738-51440045-FA5A-4931-943E-3D77D1D7ACB6Q36171831-958E868E-2BEE-4389-BA30-3574BB9C699BQ36173818-B3C18749-50DE-484B-8AD5-83A39BBA1CD9Q36201452-31A570EB-9535-4456-B692-5651C90D3C9DQ36253724-97111F25-43FE-44DD-AE0F-3F547AAAC911Q36316924-8017C737-E085-45E1-80D9-80D7E5C3F481Q36343279-D8627CF3-DF41-4293-9C4B-603B86FB12C3Q36541370-2CD81DF1-3440-4280-B35C-893F6187BE19Q36630298-A4DCFFDD-5E6B-4A6B-AE0C-73FCF51C540AQ37143313-F9DC4491-018F-4002-A3E4-B0504DD57011Q37200484-F36D57F7-4CF0-4457-BF7E-6D68E59F6779Q37957791-80E9BD90-73F1-45EB-AACA-7B40DF803B8AQ38306690-15318D9E-659C-4712-9191-038B73C281BFQ38811000-E4756E8E-CA9B-4E7E-A5FA-C2A781719564Q39945033-CB042DDF-948A-4954-955F-A908FF665580
P2860
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Human P2Y1 receptor: molecular ...... antagonist recognition sites.
@ast
Human P2Y1 receptor: molecular ...... antagonist recognition sites.
@en
type
label
Human P2Y1 receptor: molecular ...... antagonist recognition sites.
@ast
Human P2Y1 receptor: molecular ...... antagonist recognition sites.
@en
prefLabel
Human P2Y1 receptor: molecular ...... antagonist recognition sites.
@ast
Human P2Y1 receptor: molecular ...... antagonist recognition sites.
@en
P2093
P2860
P50
P356
P1476
Human P2Y1 receptor: molecular ...... d antagonist recognition sites
@en
P2093
P2860
P304
P356
10.1021/JM970684U
P407
P577
1998-04-01T00:00:00Z