about
Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptorsRat brain guanosine binding site. Biological studies and pseudo-receptor construction.Adenosine deaminase: functional implications and different classes of inhibitors.6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.Metabotropic glutamate receptors: structure and new subtype-selective ligands.Exploring the effect of PARP-1 flexibility in docking studies.Scaffold hopping approach on the route to selective tankyrase inhibitors.3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.From polypharmacology to target specificity: the case of PARP inhibitors.Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography.The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities.Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure.Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin.Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist.Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats.New substituted 9-alkylpurines as adenosine receptor ligands.Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors.Characterization of thymoquinone binding to human α₁-acid glycoprotein.Chiral separation of helical chromenes with chloromethyl phenylcarbamate polysaccharide-based stationary phases.Dexpramipexole improves bioenergetics and outcome in experimental stroke.2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.N-Decyl-S-trityl-(R)-cysteine, a new chiral selector for "green" ligand-exchange chromatography applications.Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.Fast chromatographic determination of the bile salt critical micellar concentration.Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.Evaluation of (arene)Ru(II) complexes of curcumin as inhibitors of dipeptidyl peptidase IV.Hydrophobic Amino Acid Content in Onions as Potential Fingerprints of Geographical Origin: The Case of
P50
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P50
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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Emidio Camaioni
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P106
P1153
6603785096
P21
P31
P496
0000-0002-8529-0849