Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice
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Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of diseaseAtaxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse modelMotor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive ReviewThe role of ryanodine receptor type 3 in a mouse model of Alzheimer diseaseThe RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2Computational neurobiology is a useful tool in translational neurology: the example of ataxiaTargeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin InterfaceThe role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's diseaseRecent advances in RNA interference therapeutics for CNS diseases.In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.New roles for the cerebellum in health and disease.Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis.Modulating Ca2+ release by the IP3R/Ca2+ channel as a potential therapeutic treatment for neurological diseases.Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.Inositol lipid phosphatases in membrane trafficking and human disease.Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma MultiformeDisturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.Cellular and circuit mechanisms underlying spinocerebellar ataxias.IP3 receptor mutations and brain diseases in human and rodents.Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and Purkinje cell dendritic development.Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.Downregulation of Purkinje Cell Activity by Modulators of Small Conductance Calcium-Activated Potassium Channels In Rat Cerebellum.The inositol metabolism pathway as a target for neuroprotective strategies.Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors.A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns.Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders.Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice.Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia.Expansion of the clinical phenotype of the distal 10q26.3 deletion syndrome to include ataxia and hyperemia of the hands and feet.Purkinje Cell Signaling Deficits in Animal Models of Ataxia.
P2860
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P2860
Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@ast
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@en
type
label
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@ast
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@en
prefLabel
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@ast
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@en
P2093
P2860
P1476
Chronic suppression of inosito ...... spinocerebellar ataxia 2 mice
@en
P2093
Adebimpe W Kasumu
Daria Vorontsova
Ilya Bezprozvanny
Polina Egorova
P2860
P304
12786-12796
P356
10.1523/JNEUROSCI.1643-12.2012
P407
P577
2012-09-01T00:00:00Z