Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. - Wikidata - wikimedia - TriplyDB

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

http://www.wikidata.org/entity/Q36321377

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uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil Urokinase receptor and resistance to targeted anticancer agents VEGF-initiated angiogenesis and the uPA/uPAR system Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)Leukocyte adhesion and polarization: Role of glycosylphosphatidylinositol-anchored proteins Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography.Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region.Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins.In silico docking of urokinase plasminogen activator and integrins.Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin.Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis.Extracellular matrix-associated gene expression in adult sensory neuron populations cultured on a laminin substrate.MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells.Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion Urokinase and its receptors in chronic kidney disease.Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion.Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor.Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor.Structural basis of interaction between urokinase-type plasminogen activator and its receptor Targeting integrins for the control of tumour angiogenesis.Methods for identifying novel integrin ligands Mac-1 promotes FcgammaRIIA-dependent cell spreading and migration on immune complexes.The Periodontal Pathogen Porphyromonas gingivalis Preferentially Interacts with Oral Epithelial Cells in S Phase of the Cell Cycle LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2 Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins.ECRG2 regulates cell migration/invasion through urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway.Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.Renal biopsy: use of biomarkers as a tool for the diagnosis of focal segmental glomerulosclerosis.Phagocytized beads reduce the α5β1 integrin facilitated invasiveness of cancer cells by regulating cellular stiffness.

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Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

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2005年学术文章

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2005年學術文章

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Regulation of alpha5beta1 inte ...... by urokinase receptor binding.

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Regulation of alpha5beta1 inte ...... by urokinase receptor binding.

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Regulation of alpha5beta1 inte ...... by urokinase receptor binding.

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Regulation of alpha5beta1 inte ...... by urokinase receptor binding

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P2093

Feng Zhang

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Harold A Chapman

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Jian-Ping Xiong

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Kevin K Kim

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Liliane Robillard

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Matthias C Kugler

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Ralf-Peter Czekay

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Ying Wei

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P2860

Crystal structure of the extracellular segment of integrin alpha Vbeta3

Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo

C-terminal heparin-binding domain of fibronectin regulates integrin-mediated cell spreading but not the activation of mitogen-activated protein kinase

Coming to grips with integrin binding to ligands

Taking cell-matrix adhesions to the third dimension

Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.

Integrins: roles in cancer development and as treatment targets.

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.

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Martin J. Humphries

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8048403

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2171741

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