Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly - Wikidata - wikimedia - TriplyDB

Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly

Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly

http://www.wikidata.org/entity/Q36322209

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Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP Cytosolic extract induces Tir translocation and pedestals in EPEC-infected red blood cells The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-κB activity by targeting TNFα receptor-associated factors c-Abl phosphorylates Dok1 to promote filopodia during cell spreading Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly Allosteric N-WASP activation by an inter-SH3 domain linker in Nck Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck.Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector.Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites.The Chlamydia effector TarP mimics the mammalian leucine-aspartic acid motif of paxillin to subvert the focal adhesion kinase during invasion The localized adherence pattern of an atypical enteropathogenic Escherichia coli is mediated by intimin omicron and unexpectedly promotes HeLa cell invasion.Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3 The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation.TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment.Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation Contribution of Crk adaptor proteins to host cell and bacteria interactions.Bacterial subversion of host actin dynamics at the plasma membrane.Impenetrable barriers or entry portals? The role of cell-cell adhesion during infection The gut bacterium Bacteroides thetaiotaomicron influences the virulence potential of the enterohemorrhagic Escherichia coli O103:H25 Allele- and tir-independent functions of intimin in diverse animal infection models Tir Is Essential for the Recruitment of Tks5 to Enteropathogenic Escherichia coli Pedestals.Pathogen-induced actin filament rearrangement in infectious diseases.Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2.Type III secretion systems and disease.Attaching effacing Escherichia coli and paradigms of Tir-triggered actin polymerization: getting off the pedestal.Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals.A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assembly.Sticky situation: localized adherence of enteropathogenic Escherichia coli to the small intestine epithelium.Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration

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P2860

Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly

http://www.wikidata.org/entity/Q36322209

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2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Clustering of Nck by a 12-resi ...... igger localized actin assembly

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Clustering of Nck by a 12-resi ...... igger localized actin assembly

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type

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Clustering of Nck by a 12-resi ...... igger localized actin assembly

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Clustering of Nck by a 12-resi ...... igger localized actin assembly

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prefLabel

Clustering of Nck by a 12-resi ...... igger localized actin assembly

@ast

Clustering of Nck by a 12-resi ...... igger localized actin assembly

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Journal of Cell Biology

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Clustering of Nck by a 12-resi ...... igger localized actin assembly

@en

P2093

Donald J Tipper

http://www.w3.org/2001/XMLSchema#string

John M Leong

http://www.w3.org/2001/XMLSchema#string

Kenneth G Campellone

http://www.w3.org/2001/XMLSchema#string

Marc W Kirschner

http://www.w3.org/2001/XMLSchema#string

Tony Pawson

http://www.w3.org/2001/XMLSchema#string

P2860

Diarrheagenic Escherichia coli

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

The Nck family of adapter proteins: regulators of actin cytoskeleton.

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells.

A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.

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407-416

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10.1083/JCB.200306032

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3

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164

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Susannah Rankin

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2004-02-01T00:00:00Z

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8890251

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14757753

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2172230

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