The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle.
about
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelityFunctional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceA TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridgingA minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesisMechanistic analysis of the mitotic kinesin Eg5.Monastrol inhibition of the mitotic kinesin Eg5.Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated proteinPathway of ATP hydrolysis by monomeric kinesin Eg5Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpointNercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progressionThe KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAKThe kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.KIFC1: a promising chemotherapy target for cancer treatment?The far C-terminus of MCAK regulates its conformation and spindle pole focusing.Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindleThe Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivoThe Ran-GTP gradient spatially regulates XCTK2 in the spindle.A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancerMeiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytesRecent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapyAn intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitorCDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following MitosisThe tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.An improved optical tweezers assay for measuring the force generation of single kinesin molecules.Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrolA structural model for monastrol inhibition of dimeric kinesin Eg5.Microtubule motor Ncd induces sliding of microtubules in vivoA functional relationship between NuMA and kid is involved in both spindle organization and chromosome alignment in vertebrate cellsProper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1.KLP-18, a Klp2 kinesin, is required for assembly of acentrosomal meiotic spindles in Caenorhabditis elegans.Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cellsLive-cell analysis of mitotic spindle formation in taxol-treated cells.Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.The mitotic kinesin-14 KlpA contains a context-dependent directionality switchTargeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe
P2860
Q24300214-F4F2D58A-CD60-4534-8E7B-08F0091B5C49Q24300469-64BC5BB2-B5CC-4302-8F38-674267B2CB2DQ24339378-BAB386FB-1594-4264-B89C-DE4062546FBAQ24521334-0BE7A15C-9DCE-420E-99A9-6D683DB93904Q24540197-F7144D94-49C5-456C-9EB5-F3CA71A2A7AEQ24540254-3B6DA04B-9307-4634-9BC9-2179E4114DC3Q24555066-6A1C56A4-E450-4C04-A768-8F1464048AF1Q24644762-5647FDE4-E319-4085-8F6B-5642D14C193DQ24649800-456E22CA-C67E-461C-B324-76B4E7B89215Q24674151-0FA1FA20-FCBC-4E9F-B9BA-51071C46C983Q24676906-55DCB5E0-1381-42B6-8638-E49A916D6BA9Q24679500-F803384A-C608-4DAE-A379-A8F307BF8BF7Q24682691-F538FB6E-56D2-4AB6-89A4-DC14A79D4D7AQ24685871-F9CFBA8B-7399-45DB-84CA-A335AC56401EQ26751207-239FB31E-DD84-45A0-9008-B0D93B11422CQ27304972-5BA29603-F286-40CF-A132-F1F36187C3F0Q27309082-B0EDD0CE-9D34-447B-8272-8E4F73C8DD1AQ27310316-3A4FB34F-3BC6-4E30-97ED-7AF29E676AA7Q27311109-71763135-9BE8-4A46-B9FE-4DB7735B9957Q27316189-538B68A5-DB8E-40EA-A4C2-F6C5DBD76D4AQ27323861-1E929354-71A7-4A76-8476-BA7E4ED2896BQ27438173-E9A496F0-5249-41C8-8118-5CA3371C1EE8Q28076992-83DC96E3-AD6E-4525-91C1-17FD11715B61Q28476280-4037170C-1D9C-4E53-9199-3B44516072E4Q28550165-8C7A1509-D970-4538-BAA5-8D2D27E0C4A1Q29871491-83D0CA54-5576-4F26-9FC8-870F5BD5E457Q30423655-8455CAA3-41BE-4892-B25F-F6CBD13493B0Q30477054-7EE3A130-02D1-487E-9B50-0AA69B396CF6Q30477178-6DD5F776-314C-4AA5-B292-202FF305E2E3Q30477323-10833633-735C-4BC1-818F-C9A3199B6FE3Q30479951-5E3F92BA-6E79-4231-8FAD-B8D4A1157F4AQ30480022-87DEF76B-D064-4A4E-B0C6-8804FBA8F90CQ30480145-CC5B3550-831F-4B43-9F34-7CF923CC1F46Q30486975-699A80AD-7687-4D72-A7CC-B49C3302EC67Q30487858-230553F8-C654-4CE4-87EF-1C3C3EDE9498Q30490598-B3BD70BA-F7BD-4D93-9058-4449E4EBB818Q30501259-5BE7E28A-2E5C-41AE-98FA-D9590F8E5EFFQ30656511-A83BD7A2-1679-4EB6-B66A-9B73A5CB088AQ30833924-F603682D-BC76-44C7-B611-B3EC7CA08447Q33584823-C368BFD1-9D12-4EFC-8B9E-E5259B9ED526
P2860
The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@ast
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@en
type
label
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@ast
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@en
prefLabel
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@ast
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@en
P2093
P2860
P356
P1476
The kinesin-related protein, H ...... the mammalian mitotic spindle.
@en
P2093
P2860
P304
P356
10.1083/JCB.147.2.351
P407
P577
1999-10-01T00:00:00Z