The small GTPase, Rap1, mediates CD31-induced integrin adhesion. - Wikidata - wikimedia - TriplyDB

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

http://www.wikidata.org/entity/Q36326319

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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation Rap2A links intestinal cell polarity to brush border formation Biomedicine and diseases: the Klippel-Trenaunay syndrome, vascular anomalies and vascular morphogenesis Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein.Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.Mechanism of the spatio-temporal regulation of Ras and Rap1.A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3 Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1 The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2 Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.Integrins and extracellular matrix in mechanotransduction Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A.Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1 Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction.Direct spatial control of Epac1 by cyclic AMP.Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.Mesoderm migration in Drosophila is a multi-step process requiring FGF signaling and integrin activity.Proteomic characterization of plasma membrane-proximal T cell activation responses.

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P2860

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

http://www.wikidata.org/entity/Q36326319

description

2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

@zh-my

2000年学术文章

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2000年學術文章

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2000年學術文章

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2000年學術文章

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name

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@ast

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@en

type

label

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@ast

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@en

prefLabel

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@ast

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@en

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P1433

Journal of Cell Biology

P1476

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

@en

P2093

C D Buckley

http://www.w3.org/2001/XMLSchema#string

E A Koop

http://www.w3.org/2001/XMLSchema#string

E Ross

http://www.w3.org/2001/XMLSchema#string

F J Zwartkruis

http://www.w3.org/2001/XMLSchema#string

J L Bos

http://www.w3.org/2001/XMLSchema#string

K A Reedquist

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M Salmon

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R M Wolthuis

http://www.w3.org/2001/XMLSchema#string

Y van Kooyk

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P2860

Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2

Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product

A ras-related gene with transformation suppressor activity

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31

Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31

P304

1151-1158

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P356

10.1083/JCB.148.6.1151

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6

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148

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277521023

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10725328

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2174316

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