Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.
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The prion hypothesis in Parkinson's disease: Braak to the futureNeuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein AggregationGlia and alpha-synuclein in neurodegeneration: A complex interactionAnimal modeling an oligodendrogliopathy--multiple system atrophyParkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregationα-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patientsLys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.Novel therapeutic approaches in multiple system atrophyDistinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cellsUptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts.Alpha-synuclein transfers from neurons to oligodendrocytes.Transmission of Soluble and Insoluble α-Synuclein to Mice.Models of multiple system atrophyEffects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.How strong is the evidence that Parkinson's disease is a prion disorder?Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.Potential Modes of Intercellular α-Synuclein Transmission.Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cellsTunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.Glyceraldehyde 3-phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease.The neuropathology of multiple system atrophy and its therapeutic implications.Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.Import and Export of Misfolded α-Synuclein.
P2860
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P2860
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@ast
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@en
type
label
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@ast
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@en
prefLabel
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@ast
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@en
P2093
P2860
P356
P1476
Suppression of dynamin GTPase ...... ic target for synucleinopathy.
@en
P2093
Akio Kikuchi
Atsushi Takeda
Emiko Miura
Masashi Aoki
Masatoshi Konno
Naoto Sugeno
Takafumi Hasegawa
Tsutomu Sasaki
Yasuto Itoyama
P2860
P2888
P356
10.1186/1750-1326-7-38
P577
2012-08-14T00:00:00Z
P5875
P6179
1038886182