H-2 antigens of the thymus determine lymphocyte specificity.
about
Gene vaccination with naked plasmid DNA: mechanism of CTL primingCrossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesA Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR ConformersGermline-encoded amino acids in the alphabeta T-cell receptor control thymic selectionT cells and their eons-old obsession with MHCAlpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation.Differential Response of Mouse Thymic Epithelial Cell Types to Ionizing Radiation-Induced DNA Damage.Prss16 is not required for T-cell development.Major histocompatibility restriction of antigen recognition by T cells in a recipient of haplotype mismatched human bone marrow transplantation.Self recognition in allogeneic thymic chimeras. Self recognition by T helper cells from thymus-engrafted nude mice is restricted to the thymic H-2 haplotype.Positive selection of a T-cell subpopulation in the thymus in which it develops.A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products.Intrathymic maturation of murine T lymphocytes from CD8+ precursorsTandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genesLymphocytes. 1. Function. Genetic restrictions in the immune responseThymic selection revisited: how essential is it?On the role of self-recognition in T cell responses to foreign antigen.Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selectionT cells respond preferentially to antigens that are similar to self H-2.Evolutionarily conserved features contribute to αβ T cell receptor specificityClass II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient miceA constant affinity threshold for T cell tolerance.Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells.Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestineTolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymusSpecificity of cytotoxicity T cells directed to influenza virus hemagglutinin.Adaptive differentiation of murine lymphocytes. II. The thymic microenvironment does not restrict the cooperative partner cell preference of helper T cells differentiating in F1 leads to F1 thymic chimeras.Binding of purified, soluble major histocompatibility complex polypeptide chains onto isolated T-cell receptors. I. Reactivity against allo- and self-determinants.Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens.Specificity of cytotoxic T cells from athymic miceSendai virus-specific, H-2-restricted cytotoxic T lymphocyte responses of nude mice grafted with allogeneic or semi-allogeneic thymus glands.Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.A specific biosynthetic marker for immature thymic lymphoblasts. Active synthesis of thymus-leukemia antigen restricted to proliferating cells.B lymphocyte immune response gene phenotype is genetically determined.T cells from fully H-2 allogeneic (A replaced by B) radiation bone marrow chimeras are functionally competent and host restricted but are alloreactive against hybrid Ia determinants expressed on (A x B)F1 cells.Tolerance of thymocytes to allogeneic I region determinants encountered prethymically. Evidence for expression of anti-Ia receptors by T cell precursors before their entry into the thymus.Genetic control of the immune response to myoglobins. Both low and high responder T cells tolerant to the other major histocompatibility complex help high but not low responder B cells.Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cellsEarly development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.
P2860
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P2860
H-2 antigens of the thymus determine lymphocyte specificity.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年学术文章
@wuu
1978年学术文章
@zh-cn
1978年学术文章
@zh-hans
1978年学术文章
@zh-my
1978年学术文章
@zh-sg
1978年學術文章
@yue
1978年學術文章
@zh
1978年學術文章
@zh-hant
name
H-2 antigens of the thymus determine lymphocyte specificity.
@ast
H-2 antigens of the thymus determine lymphocyte specificity.
@en
type
label
H-2 antigens of the thymus determine lymphocyte specificity.
@ast
H-2 antigens of the thymus determine lymphocyte specificity.
@en
prefLabel
H-2 antigens of the thymus determine lymphocyte specificity.
@ast
H-2 antigens of the thymus determine lymphocyte specificity.
@en
P2860
P356
P1476
H-2 antigens of the thymus determine lymphocyte specificity.
@en
P2093
P2860
P304
P356
10.1084/JEM.148.3.766
P407
P577
1978-09-01T00:00:00Z