Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis
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N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin bindingHaemochromatosisThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapyA computational model of liver iron metabolismCarriers of the Complex Allele HFE c.[187C>G;340+4T>C] Have Increased Risk of Iron Overload in São Miguel Island Population (Azores, Portugal)Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and humanEffects of HFE C282Y and H63D polymorphisms and polygenic background on iron stores in a large community sample of twins.Variants in iron metabolism genes predict higher blood lead levels in young children.Infection with Mycobacterium avium differentially regulates the expression of iron transport protein mRNA in murine peritoneal macrophages.Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.Sequence variation and haplotype structure at the human HFE locus.Traffic jam: a compendium of human diseases that affect intracellular transport processes.Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor.A method for detecting recent selection in the human genome from allele age estimates.The hemochromatosis protein HFE inhibits iron export from macrophages.Physiology of iron transport and the hemochromatosis gene.Molecular testing for hereditary hemochromatosis.Molecular pathogenesis of iron overload.Erythroblast iron metabolism in sideroblastic and sideropenic states.Molecular mechanisms and regulation of iron transport.Phlebotomy increases cadmium uptake in hemochromatosis.Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.Variable phenotypic presentation of iron overload in H63D homozygotes: are genetic modifiers the cause?Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls.Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosisLiver iron transportThe alpha1a-adrenergic receptor occupies membrane rafts with its G protein effectors but internalizes via clathrin-coated pits.The regulation of cellular iron metabolism.The evolutionary adaptation of the C282Y mutation to culture and climate during the European Neolithic.Molecular basis of hereditary iron homeostasis defects.Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments.Targeted delivery of transferrin and TAT co-modified liposomes encapsulating both paclitaxel and doxorubicin for melanoma.A hybrid approach to measuring electrical activity in genetically specified neurons.Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells.The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.Localisation of proteins of iron metabolism in the human placenta and liver.Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alphaIron-overload and genotypic expression of HFE mutations H63D/C282Y and transferrin receptor Hin6I and BanI polymorphism in german patients with hereditary haemochromatosis.
P2860
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P2860
Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Transferrin receptor is negati ...... for cellular iron homeostasis
@ast
Transferrin receptor is negati ...... for cellular iron homeostasis
@en
type
label
Transferrin receptor is negati ...... for cellular iron homeostasis
@ast
Transferrin receptor is negati ...... for cellular iron homeostasis
@en
prefLabel
Transferrin receptor is negati ...... for cellular iron homeostasis
@ast
Transferrin receptor is negati ...... for cellular iron homeostasis
@en
P2093
P2860
P356
P1476
Transferrin receptor is negati ...... for cellular iron homeostasis
@en
P2093
A Brunmark
L Salter-Cid
M R Jackson
P A Peterson
P2860
P304
P356
10.1073/PNAS.96.10.5434
P407
P577
1999-05-01T00:00:00Z