Systemic autoimmune disease arises from polyclonal B cell activation.
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Autoimmune Hemolysis: A Journey through TimeAutoimmunity, polyclonal B-cell activation and infectionPeroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritisAnti-insulin antibodies and the natural autoimmune response in systemic lupus erythematosus.Properties of the ribosomal P2 protein autoantigen are similar to those of foreign protein antigens.Identification of murine complement receptor type 2Role of antigen selectivity in autoimmune responses to the Ku (p70/p80) antigenIndependently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequencesThe role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunityInterleukin 6 promotes murine lupus in NZB/NZW F1 mice.The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.Anti-DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus.Origin and regulation of a disease-specific autoantibody response. Antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 autoantibodies.In vitro autoantibody production by normal adult and cord blood B cells.Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypesPolyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease.Natural murine autoantibodies and conventional antibodies exhibit similar degrees of antigenic cross-reactivity.Oxygen free radicals and systemic autoimmunity.Development of human antibody variable genes in systemic autoimmunity.Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation.Definition of a discontinuous immunodominant epitope at the NH2 terminus of the La/SS-B ribonucleoprotein autoantigen.Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus.Involvement of dendritic cells in autoimmune diseases in children.B cell tolerance and positive selection in lupus.Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient.Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.Human anti-p68 autoantibodies recognize a common epitope of U1 RNA containing small nuclear ribonucleoprotein and influenza B virus.An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal miceThymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune diseaseMonoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue.Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cellsRole of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses.Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW)F1 mice.Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice.Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice.An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes.
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P2860
Systemic autoimmune disease arises from polyclonal B cell activation.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Systemic autoimmune disease arises from polyclonal B cell activation.
@ast
Systemic autoimmune disease arises from polyclonal B cell activation.
@en
type
label
Systemic autoimmune disease arises from polyclonal B cell activation.
@ast
Systemic autoimmune disease arises from polyclonal B cell activation.
@en
prefLabel
Systemic autoimmune disease arises from polyclonal B cell activation.
@ast
Systemic autoimmune disease arises from polyclonal B cell activation.
@en
P2860
P356
P1476
Systemic autoimmune disease arises from polyclonal B cell activation.
@en
P2093
Klinman DM
Steinberg AD
P2860
P304
P356
10.1084/JEM.165.6.1755
P407
P577
1987-06-01T00:00:00Z