Developmentally regulated and strain-specific expression of murine VH gene families.
about
A deletion map of the human immunoglobulin heavy chain variable regionThe analysis of clonal expansions in normal and autoimmune B cell repertoiresA novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.Most peripheral B cells in mice are ligand selected.Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult miceStochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cellsPreferential rearrangement of V kappa 4 gene segments in pre-B cell lines.DNA vaccination and the immune responsiveness of neonates.Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire.Cell-surface expression of transrearranged Vgamma-cbeta T-cell receptor chains in healthy donors and in ataxia telangiectasia patients.Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesEarly rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adultsSoma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC: The manifest polymorphism of the MHC appears greatly exceeded at Immunoglobulin loci, suggesting antigen-selected somatic V mutants penetrate Weismann's BarrieDeterminism and stochasticity during maturation of the zebrafish antibody repertoireCis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern.Expansion, selection and mutation of antigen-specific B cells in germinal centers.Surface markers, heavy chain sequences and B cell lineages.Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses.Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells.Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation.Development and selection of marginal zone B cells.Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice.The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of familiesRegulation of immunoglobulin heavy-chain gene rearrangements.VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.The human VH repertoire: a restricted set of VH genes may be the target of immune regulation.Expression of V gene families during ontogeny and establishment of B cell repertoire.Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-mu heavy chain gene.High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice.Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseDifferential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic miceClonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationBiased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.
P2860
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P2860
Developmentally regulated and strain-specific expression of murine VH gene families.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh
1988年學術文章
@zh-hant
name
Developmentally regulated and strain-specific expression of murine VH gene families.
@ast
Developmentally regulated and strain-specific expression of murine VH gene families.
@en
type
label
Developmentally regulated and strain-specific expression of murine VH gene families.
@ast
Developmentally regulated and strain-specific expression of murine VH gene families.
@en
prefLabel
Developmentally regulated and strain-specific expression of murine VH gene families.
@ast
Developmentally regulated and strain-specific expression of murine VH gene families.
@en
P2093
P2860
P356
P1476
Developmentally regulated and strain-specific expression of murine VH gene families.
@en
P2093
B A Malynn
G D Yancopoulos
P2860
P304
P356
10.1084/JEM.168.1.417
P407
P577
1988-07-01T00:00:00Z