The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.
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Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent mannerProline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityBinding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulationSERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefMutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsActivation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complexLeucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexesThe restriction factors of human immunodeficiency virusNuclear localization signal of HIV-1 as a novel target for therapeutic interventionThe Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrixInterleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathwayThe association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependentHuman immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase familyInteraction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivityReplicative homeostasis: a fundamental mechanism mediating selective viral replication and escape mutationHIV: master of the host cell.Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages by using twins.A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 NefHuman immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell deathThe identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancementHIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particlesLentivirus Nef specifically activates Pak2.Intrinsic cellular defenses against human immunodeficiency virusesIn vitro exposure system for study of aerosolized influenza virusA consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophagesHIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenonThe HIV-1 Nef protein as a target for antiretroviral therapy.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.Human T-lymphotropic virus type 1 open reading frame I p12(I) is required for efficient viral infectivity in primary lymphocytes.Regions of human immunodeficiency virus type 1 nef required for function in vivoRole of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaquesThe SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Refined solution structure and backbone dynamics of HIV-1 Nef.Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivityNef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142
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P2860
The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@ast
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@en
type
label
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@ast
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@en
prefLabel
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@ast
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@en
P2093
P2860
P356
P1476
The human immunodeficiency vir ...... y lymphocytes and macrophages.
@en
P2093
M B Feinberg
M D Miller
M T Warmerdam
W C Greene
P2860
P304
P356
10.1084/JEM.179.1.101
P407
P577
1994-01-01T00:00:00Z