Residues crucial for Ras interaction with GDP-GTP exchangers.
about
Structure of the Sec7 domain of the Arf exchange factor ARNOBasis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factorsDifferential activation of yeast adenylyl cyclase by Ras1 and Ras2 depends on the conserved N terminus.An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.Decreased GTPase activity of K-ras mutants deriving from human functional adrenocortical tumoursIdentification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets.Distinct subclasses of small GTPases interact with guanine nucleotide exchange factors in a similar manner."Peptide walking" is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase.Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements.Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development.
P2860
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P2860
Residues crucial for Ras interaction with GDP-GTP exchangers.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Residues crucial for Ras interaction with GDP-GTP exchangers.
@ast
Residues crucial for Ras interaction with GDP-GTP exchangers.
@en
type
label
Residues crucial for Ras interaction with GDP-GTP exchangers.
@ast
Residues crucial for Ras interaction with GDP-GTP exchangers.
@en
prefLabel
Residues crucial for Ras interaction with GDP-GTP exchangers.
@ast
Residues crucial for Ras interaction with GDP-GTP exchangers.
@en
P2093
P2860
P356
P1476
Residues crucial for Ras interaction with GDP-GTP exchangers.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.12.5564
P407
P577
1993-06-01T00:00:00Z