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Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

http://www.wikidata.org/entity/Q36364894

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation BH3 domains other than Bim and Bid can directly activate Bax/Bak Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells BH3-only proteins: a 20-year stock-take The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2 Modeling a snap-action, variable-delay switch controlling extrinsic cell death Spatial and temporal changes in Bax subcellular localization during anoikis Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells Mitochondria: in sickness and in health Translocation of full-length Bid to mitochondria during anoikis.Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis.Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA)Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells.The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins.Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario.Cardioprotective effect of erythropoietin on sepsis-induced myocardial injury in rats.The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor.Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis.p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.Small-molecule Bax agonists for cancer therapy.Study of PTPC composition during apoptosis for identification of viral protein target.Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice.Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis.

P2860

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P2860

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

http://www.wikidata.org/entity/Q36364894

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

@zh-my

2001年学术文章

@zh-sg

2001年學術文章

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2001年學術文章

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2001年學術文章

@zh-hant

name

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@ast

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@en

type

label

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@ast

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@en

prefLabel

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@ast

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@en

P1433

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P1433

Journal of Cell Biology

P1476

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

@en

P2093

Lamensdorf I

http://www.w3.org/2001/XMLSchema#string

Nechushtan A

http://www.w3.org/2001/XMLSchema#string

Smith CL

http://www.w3.org/2001/XMLSchema#string

Yoon SH

http://www.w3.org/2001/XMLSchema#string

Youle RJ

http://www.w3.org/2001/XMLSchema#string

P2860

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

Inhibition of Bax channel-forming activity by Bcl-2

P304

1265-1276

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P31

scholarly article

P356

10.1083/JCB.153.6.1265

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P407

P433

6

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P478

153

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2001-06-01T00:00:00Z

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P5875

236243076

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P698

11402069

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P921

apoptotic process

P932

2192024

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