Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
about
Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic functionAcute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndromeThe discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and diseaseNovel Inhibitors Complexed with Glutamate Dehydrogenase: ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICSTransamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretionParticipation of endogenous fatty acids in the secretory activity of the pancreatic B-cellPractical management of hyperinsulinism in infancyKetone bodies and islet function: 86Rb handling and metabolic data.Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain.Disorders of glutamate metabolism.The complex mechanism of glutamate dehydrogenase in insulin secretion.The structure and allosteric regulation of mammalian glutamate dehydrogenase.Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.Involvement of GDH3-encoded NADP+-dependent glutamate dehydrogenase in yeast cell resistance to stress-induced apoptosis in stationary phase cellsHigh throughput screening reveals several new classes of glutamate dehydrogenase inhibitorsGlucose-modulated tyrosine nitration in beta cells: targets and consequences.Glutamate dehydrogenase activator BCH stimulating reductive amination prevents high fat/high fructose diet-induced steatohepatitis and hyperglycemia in C57BL/6J mice.The structure and allosteric regulation of glutamate dehydrogenase.Glutamate dehydrogenase: structure, allosteric regulation, and role in insulin homeostasis.The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion.13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation.Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats.Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue.Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids.Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex.Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point.Hyperinsulinism-hyperammonemia syndrome in an infant with seizures
P2860
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P2860
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
description
1981 nî lūn-bûn
@nan
1981年の論文
@ja
1981年学术文章
@wuu
1981年学术文章
@zh-cn
1981年学术文章
@zh-hans
1981年学术文章
@zh-my
1981年学术文章
@zh-sg
1981年學術文章
@yue
1981年學術文章
@zh
1981年學術文章
@zh-hant
name
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@ast
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@en
type
label
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@ast
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@en
prefLabel
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@ast
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@en
P2093
P2860
P356
P1476
Stimulation of pancreatic isle ...... a nonmetabolizable amino acid.
@en
P2093
Malaisse WJ
Malaisse-Lagae F
P2860
P304
P356
10.1073/PNAS.78.9.5460
P407
P577
1981-09-01T00:00:00Z