CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes
about
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferationInterferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cellsFunctional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptorThe multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsStructural Basis of the CD8 /MHC Class I Interaction: Focused Recognition Orients CD8 to a T Cell Proximal PositionCD3 delta establishes a functional link between the T cell receptor and CD8Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagementCD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers.CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation.Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabetaDifferential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.TCR signal initiation machinery is pre-assembled and activated in a subset of membrane raftsSialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.CTLA-4 negative signaling via lipid rafts: A new perspective.Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune moleculesOptimal T-cell receptor affinity for inducing autoimmunity.Extracellular domains of CD8α and CD8ß subunits are sufficient for HLA class I restricted helper functions of TCR-engineered CD4(+) T cells.T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit.Contrasting alloreactive CD4+ and CD8+ T cells: there's more to it than MHC restriction.The roles of membrane microdomains (rafts) in T cell activation.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.Profiling the CD8low phenotype, an alternative career choice for CD8 T cells during primary differentiation.Membrane domains in lymphocytes - from lipid rafts to protein scaffolds.Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse.Weak self-association in a carbohydrate systemPalmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8+ T-cells.Phase fluctuations on the micron-submicron scale in GUVs composed of a binary lipid mixture.Condensation of the plasma membrane at the site of T lymphocyte activationModulation of MHC binding by lateral association of TCR and coreceptor.Lipid rafts in lymphocyte activation and migration.Lipid rafts, detergent-resistant membranes, and raft targeting signals.T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation.Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine.
P2860
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P2860
CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@ast
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@en
type
label
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@ast
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@en
prefLabel
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@ast
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@en
P2093
P2860
P50
P356
P1476
CD8beta endows CD8 with effici ...... ociated CD8/p56(lck) complexes
@en
P2093
C Grégoire
I F Luescher
T R Bakker
P2860
P304
P356
10.1084/JEM.194.10.1485
P407
P577
2001-11-01T00:00:00Z