Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
about
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activationCloning of ACP33 as a novel intracellular ligand of CD4Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cellsNTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative diseaseAgeing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune systemQuantitative differences in lipid raft components between murine CD4+ and CD8+ T cellsLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysCD3 delta establishes a functional link between the T cell receptor and CD8CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation.Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection.The T cell receptor for antigen: signaling and ligand discrimination.Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clustersThe transmembrane adapter LAT plays a central role in immune receptor signalling.Signalling scaffolds and adaptors in T-cell immunity.A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transductionThe human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties.T-cell development and the CD4-CD8 lineage decision.Extracellular domains of CD8α and CD8ß subunits are sufficient for HLA class I restricted helper functions of TCR-engineered CD4(+) T cells.An evolutionary and structural perspective on T cell antigen receptor function.CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1.Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assembliesCD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexesAn antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection.Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.Tricks with tetramers: how to get the most from multimeric peptide-MHC.CD4 and CD8: an inside-out coreceptor model for innate immune cells.IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.TL and CD8αα: Enigmatic partners in mucosal immunity.The molecular determinants of CD8 co-receptor function.The role of MHC class Ib-restricted T cells during infection.LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.Altered proximal T-cell receptor signalling events in mouse CD4+ T cells in the presence of anti-CD4 monoclonal antibodies: evidence for reduced phosphorylation of Zap-70 and LAT.Sustained linked stimulation via CD3 and CD4 is required for the IL-4-independent development of IL-4 synthesizing CD4+ T cells.The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.
P2860
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P2860
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Association of the adaptor mol ...... l receptor signal transduction
@ast
Association of the adaptor mol ...... l receptor signal transduction
@en
Association of the adaptor mol ...... l receptor signal transduction
@nl
type
label
Association of the adaptor mol ...... l receptor signal transduction
@ast
Association of the adaptor mol ...... l receptor signal transduction
@en
Association of the adaptor mol ...... l receptor signal transduction
@nl
prefLabel
Association of the adaptor mol ...... l receptor signal transduction
@ast
Association of the adaptor mol ...... l receptor signal transduction
@en
Association of the adaptor mol ...... l receptor signal transduction
@nl
P2093
P2860
P356
P1476
Association of the adaptor mol ...... l receptor signal transduction
@en
P2093
P2860
P304
P356
10.1084/JEM.190.10.1517
P407
P577
1999-11-15T00:00:00Z