Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
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Keeping mtDNA in shape between generationsModulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy childrenMitochondrial DNA disease and developmental implications for reproductive strategiesSegregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig ModelValidation of Next-Generation Sequencing of Entire Mitochondrial Genomes and the Diversity of Mitochondrial DNA Mutations in Oral Squamous Cell Carcinoma.Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing.Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humansTissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage.Somatic mtDNA mutation spectra in the aging human putamen.Origins and functional consequences of somatic mitochondrial DNA mutations in human cancerExtreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in HumansMitochondrial activity in gametes and transmission of viable mtDNAOocyte mitochondrial function and reproduction.Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms.Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.Mitochondria as a target of environmental toxicants.Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Dynamic regulation of mitochondrial genome maintenance in germ cells.No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline.Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) geneSelective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant.Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection.Loss of LRPPRC causes ATP synthase deficiencyMitochondrial matters: Mitochondrial bottlenecks, self-assembling structures, and entrapment in the female germline.Genetic Counselling for Maternally Inherited Mitochondrial Disorders.Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division.Length variation in the mouse mitochondrial tRNA(Arg) DHU loop size promotes oxidative phosphorylation functional differences.Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.
P2860
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P2860
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Variation in germline mtDNA he ...... uring subsequent transmission.
@ast
Variation in germline mtDNA he ...... uring subsequent transmission.
@en
type
label
Variation in germline mtDNA he ...... uring subsequent transmission.
@ast
Variation in germline mtDNA he ...... uring subsequent transmission.
@en
prefLabel
Variation in germline mtDNA he ...... uring subsequent transmission.
@ast
Variation in germline mtDNA he ...... uring subsequent transmission.
@en
P2093
P2860
P50
P356
P1433
P1476
Variation in germline mtDNA he ...... uring subsequent transmission.
@en
P2093
Camilla Koolmeister
Dusanka Milenkovic
Emmanouella E Chatzidaki
Erik Hagström
Rudolf J Wiesner
Vasileios I Floros
P2860
P2888
P304
P356
10.1038/NG.2427
P407
P50
P577
2012-10-07T00:00:00Z
P5875
P6179
1022191368