Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype.
about
In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.Oligonucleotides with rapid turnover of the phosphate groups occur endogenously in eukaryotic cells.Tunicamycin tightens the glucose- and D-allose-mediated control of hexose transport in a metabolic fibroblast mutant.Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinaseCD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.Insulin binding and insulin action in cultured fibroblasts: significant differences between a phosphoglucose isomerase-deficient mutant and the parental strainGlycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell SurvivalStudies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.Further clues concerning the vectors essential to regulation of hexose transport, as studied in fibroblast cultures from a metabolic mutantDown-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomeraseGrowth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.Sulfate suicide selection of Dictyostelium discoideum mutants defective in protein glycosylation.Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras.Selection of mutant Chinese hamster ovary cells altered glycoproteins by means of tritiated fucose suicide.Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.Hexose transport control in a fibroblast metabolic mutant can be promoted more effectively by D-allose than by glucose.A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.Mutations in the phosphoglucose isomerase gene can lead to marked alterations in cellular ATP levels in cultured fibroblasts exposed to simple nutrient shifts.Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.Nutritional and physiological consequences of tumour glycolysis.The Na+/H+ antiporter potentiates growth and retinoic acid-induced differentiation of P19 embryonal carcinoma cells.Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.Transport and accumulation of 2-deoxy-D-glucose in wild-type and hexokinase-deficient cultured Chinese-hamster ovary (CHO) cells.Purines as 'hyper-repressors' of glucose transport. A role for phosphoribosyl diphosphate.Hyperthermia, Na+K+ATPase and lactic acid production in some human tumour cells.Developmental potential and survival of glycolysis-deficient cells in fetal mouse chimeras.The pentose phosphate pathway: evidence for the indispensable role of glucose-phosphate isomerase.Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia.High-affinity neurotensin binding sites in differentiated neuroblastoma N1E115 cells.Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs.
P2860
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P2860
Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年学术文章
@wuu
1980年学术文章
@zh-cn
1980年学术文章
@zh-hans
1980年学术文章
@zh-my
1980年学术文章
@zh-sg
1980年學術文章
@yue
1980年學術文章
@zh
1980年學術文章
@zh-hant
name
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@ast
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@en
type
label
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@ast
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@en
prefLabel
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@ast
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@en
P2093
P2860
P356
P1476
Isolation of a Chinese hamster ...... ssect the malignant phenotype.
@en
P2093
Pouysségur J
Salomon JC
Silvestre P
P2860
P304
P356
10.1073/PNAS.77.5.2698
P407
P577
1980-05-01T00:00:00Z