Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.
about
The current understanding of trauma-induced coagulopathy (TIC): a focused review on pathophysiologyDevelopment and validation of a high throughput whole blood thrombolysis plate assay.Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trialUpdated concepts on the pathophysiology and the clinical management of trauma hemorrhage and coagulopathy.Advances in the understanding of trauma-induced coagulopathyPostinjury fibrinolysis shutdown: Rationale for selective tranexamic acidAcute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients.Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes.Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype.Progresses in understanding trauma-induced coagulopathy and the underlying mechanism.Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and ConsequencesHemorrhagic blood failure: Oxygen debt, coagulopathy, and endothelial damage.Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility: A case-control study.Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis.Measuring fibrinolysis: from research to routine diagnostic assays.Acute Traumatic Endotheliopathy in Isolated Severe Brain Injury and Its Impact on Clinical Outcome.Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.The hyperfibrinolytic phenotype is the most lethal and resource intense presentation of fibrinolysis in massive transfusion patients.Abnormalities of laboratory coagulation tests versus clinically evident coagulopathic bleeding: results from the prehospital resuscitation on helicopters study (PROHS).Correlation of pre-operative plasma protein concentrations in cardiac surgery patients with bleeding outcomes using a targeted quantitative proteomics approach.Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque).Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness Such as Trauma or Sepsis?Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury.Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage.7.5% NaCl Resuscitation Leads to Abnormal Clot Fibrinolysis after Severe Hemorrhagic Shock and its Correction with 7.5% NaCl Adenosine, Lidocaine, and Mg2.Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients.Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review.Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial
P2860
Q29994525-8A6DEFE5-F891-47E2-AF2F-1F71D357661BQ33725847-77B9123B-8E22-4EA2-9E9F-B3B982C430D3Q33733392-2FD2EAB0-2E58-47C8-B44F-01968D0E31A1Q33807522-96C47F03-636F-4764-8AAE-D0C29DB65A44Q34677754-33258D0C-17F6-46F1-B454-EA938BEC92FFQ35646892-B3D8C42C-1A92-45B5-BCD2-8819B41568DEQ36807586-7611397B-2CFE-437C-8E76-F2E7800D9B2CQ37615859-7879710A-3D74-45E0-99F2-29A863903577Q38776292-3826ECAF-103C-4A60-89C5-4353ED39C3CBQ39176846-EC21D588-9F0B-432A-92C4-546F0AA0B5A9Q39336502-64FFA28D-BE9D-4D42-A961-E99E45C250D1Q39454234-37120F89-47F4-4E66-B01E-F5890FE45445Q43464829-A0392FC1-45BB-4200-9A05-84B459AAE425Q47097868-1F5FE207-350F-42D7-8EDF-2BF11DC32175Q47347417-162016C6-AB11-4D53-8EF4-1B9C223FC4F7Q47593893-11F06947-3426-4A3A-8421-FE4957CB6098Q47715508-1EC4B670-BD14-4B14-B556-E616D79BFEEEQ47862399-55932797-3864-4D15-93D9-95946EC460B6Q47911192-8B365E5E-D85F-444C-8987-9897BF10A53EQ47979226-DFBB48C3-E33A-4F6A-B450-84E66A38E5D8Q48526729-49B02DB1-17A7-4E41-9A8C-F0F118112944Q48839146-F90C56D1-DC6A-48C2-B1E8-23FE11834146Q49200827-82046399-ED69-4F21-A8C6-D21FBA3D048CQ51332285-E36DB3B4-5C32-412D-82A2-48B6E512F35DQ52689153-F5F5B65F-5AC3-4580-9D95-B5A2E0F9ACF7Q54943883-AFA0B6E1-5549-4F3C-A7E7-C75166150FD5Q55001681-F35A50C0-A8C3-4094-AA6F-1AA5AA96DC80Q55277536-5BD58FFB-F0DA-466F-8AA9-E60D90DA60B8Q55312148-6385D04F-D83A-4B7A-902B-5C354D5F1C24Q57821341-40738B1E-FB6C-49CD-8FC0-17CD0EBD6781
P2860
Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Overwhelming tPA release, not ...... erely injured trauma patients.
@ast
Overwhelming tPA release, not ...... erely injured trauma patients.
@en
type
label
Overwhelming tPA release, not ...... erely injured trauma patients.
@ast
Overwhelming tPA release, not ...... erely injured trauma patients.
@en
prefLabel
Overwhelming tPA release, not ...... erely injured trauma patients.
@ast
Overwhelming tPA release, not ...... erely injured trauma patients.
@en
P2093
P2860
P1476
Overwhelming tPA release, not ...... erely injured trauma patients.
@en
P2093
Angela Sauaia
Anirban Banerjee
Arsen Ghasabyan
Christopher C Silliman
Eduardo Gonzalez
Ernest E Moore
Fabia Gamboni
Hunter B Moore
James G Chandler
Michael P Chapman
P2860
P304
16-23; discussion 23-5
P356
10.1097/TA.0000000000000885
P577
2015-10-21T00:00:00Z