The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
about
The JIP group of mitogen-activated protein kinase scaffold proteinsInterchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular functionJNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosisInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3Phorbol esters and cAMP differentially regulate the expression of CD4 and CD8 in human thymocytesModulating sensitivity to drug-induced apoptosis: the future for chemotherapy?Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytesIncreased Thymic Cell Turnover under Boron Stress May Bypass TLR3/4 Pathway in African OstrichThe POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.Genetic control of programmed cell death during animal development.Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiationConference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?Signal transduction by MAP kinases in T lymphocytes.Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoterA requirement for sustained ERK signaling during thymocyte positive selection in vivo.Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)Receptor-mediated apoptosis in T lymphocytes.Partners in transcription: NFAT and AP-1.Life and death in the thymus--cell death signaling during T cell development.JNK and p38 MAP kinases in CD4+ and CD8+ T cells.Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytesCD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes.Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitnessMAP kinase phosphatase activity sets the threshold for thymocyte positive selectionInterleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer.Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivoc-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferationThe stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cellsBeta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.Regulation of Ras signal transduction during T cell development and activation.Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
P2860
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P2860
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@ast
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@en
type
label
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@ast
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@en
prefLabel
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@ast
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@en
P2093
P2860
P356
P1476
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes
@en
P2093
B Dérijard
R A Flavell
P2860
P304
P356
10.1084/JEM.188.10.1817
P407
P577
1998-11-01T00:00:00Z