about
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell deathBuilding the backbone: the development and evolution of vertebral patterningFunctional characterisation of the maturation of the blood-brain barrier in larval zebrafishPICALM modulates autophagy activity and tau accumulation.Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects.Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.Complex inhibitory effects of nitric oxide on autophagysiRNA screen identifies QPCT as a druggable target for Huntington's disease.Chemical modulators of autophagy as biological probes and potential therapeutics.Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.Compromised autophagy and neurodegenerative diseases.Expression and regulation of drug transporters in vertebrate neutrophils.IGF-1 receptor antagonism inhibits autophagy.Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.High-throughput in vivo screening for bone anabolic compounds with zebrafish.Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae.Molecular analysis of axon repulsion by the notochord.Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish.A rapid, high content, in vivo model of glucocorticoid-induced osteoporosis.Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.A central role for the notochord in vertebral patterning.Embryonic folate metabolism and mouse neural tube defects.Non-associative learning in larval zebrafish.Seeing is believing: methods to monitor vertebrate autophagyZebrafish based assays for the assessment of cardiac, visual and gut function--potential safety screens for early drug discoverycGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Angeleen Fleming
@ast
Angeleen Fleming
@en
Angeleen Fleming
@es
Angeleen Fleming
@nl
type
label
Angeleen Fleming
@ast
Angeleen Fleming
@en
Angeleen Fleming
@es
Angeleen Fleming
@nl
prefLabel
Angeleen Fleming
@ast
Angeleen Fleming
@en
Angeleen Fleming
@es
Angeleen Fleming
@nl
P106
P1153
7202763258
P31
P496
0000-0003-3721-7126