Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein
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Wine polyphenols: potential agents in neuroprotectionOxidative Stress Signaling in Alzheimers DiseaseSignaling effect of amyloid-beta(42) on the processing of AbetaPPPro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's DiseaseResearch progress on flavonoids isolated from traditional Chinese medicine in treatment of Alzheimer's diseaseThe Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related GenesAmyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive declineModeling an anti-amyloid combination therapy for Alzheimer's disease.Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's diseasePermeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation.Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND).Mitochondrial superoxide: a key player in Alzheimer's diseaseIntraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic miceViable mouse gene ablations that robustly alter brain Aβ levels are rare.Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cellsRAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environmentEvidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats.Abnormal amyloid β42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease.Smoking and increased Alzheimer's disease risk: a review of potential mechanismsCauses versus effects: the increasing complexities of Alzheimer's disease pathogenesis.γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.D-beta-hydroxybutyrate extends lifespan in C. elegans.Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosisOxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor proteinHigh glucose promotes Aβ production by inhibiting APP degradation.A mitocentric view of Alzheimer's disease suggests multi-faceted treatmentsEndoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells.Roles of oxidative stress, apoptosis, PGC-1α and mitochondrial biogenesis in cerebral ischemia.Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseMitochondrial medicine for aging and neurodegenerative diseasesOxidative Stress and Its Clinical Applications in DementiaReduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.
P2860
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P2860
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Oxidative stress activates a p ...... beta-amyloid precursor protein
@ast
Oxidative stress activates a p ...... beta-amyloid precursor protein
@en
type
label
Oxidative stress activates a p ...... beta-amyloid precursor protein
@ast
Oxidative stress activates a p ...... beta-amyloid precursor protein
@en
prefLabel
Oxidative stress activates a p ...... beta-amyloid precursor protein
@ast
Oxidative stress activates a p ...... beta-amyloid precursor protein
@en
P2093
P2860
P50
P1476
Oxidative stress activates a p ...... beta-amyloid precursor protein
@en
P2093
Elena Tamagno
Giuseppe Muraca
Luca Giliberto
Manuela Aragno
Massimo Tabaton
Michela Guglielmotto
Oliviero Danni
Roberta Borghi
P2860
P304
P356
10.1111/J.1471-4159.2007.05072.X
P407
P577
2007-11-14T00:00:00Z