Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein - Wikidata - wikimedia - TriplyDB

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

http://www.wikidata.org/entity/Q36417576

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Wine polyphenols: potential agents in neuroprotection Oxidative Stress Signaling in Alzheimers Disease Signaling effect of amyloid-beta(42) on the processing of AbetaPP Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease Research progress on flavonoids isolated from traditional Chinese medicine in treatment of Alzheimer's disease The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline Modeling an anti-amyloid combination therapy for Alzheimer's disease.Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation.Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND).Mitochondrial superoxide: a key player in Alzheimer's disease Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice Viable mouse gene ablations that robustly alter brain Aβ levels are rare.Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats.Abnormal amyloid β42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease.Smoking and increased Alzheimer's disease risk: a review of potential mechanisms Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis.γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.D-beta-hydroxybutyrate extends lifespan in C. elegans.Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein High glucose promotes Aβ production by inhibiting APP degradation.A mitocentric view of Alzheimer's disease suggests multi-faceted treatments Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells.Roles of oxidative stress, apoptosis, PGC-1α and mitochondrial biogenesis in cerebral ischemia.Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease Mitochondrial medicine for aging and neurodegenerative diseases Oxidative Stress and Its Clinical Applications in Dementia Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.

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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

http://www.wikidata.org/entity/Q36417576

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Journal of Neurochemistry

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Massimo Tabaton

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P2860

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Pathways towards and away from Alzheimer's disease

Alzheimer's disease: genes, proteins, and therapy

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage

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5842005

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