Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.
about
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingStructural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional TargetsEmerging concepts of epigenetic dysregulation in hematological malignanciesKDM1 class flavin-dependent protein lysine demethylasesAntagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiationLANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complexHistone Demethylases in Colon Cancer.Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiationLoss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells.Epigenetic regulation of LSD1 during mammary carcinogenesis.The TCR γδ repertoire and relative gene expression characteristics of T-ALL cases with biclonal malignant Vδ1 and Vδ2 T cells.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells.A comprehensive review of lysine-specific demethylase 1 and its roles in cancer.Silencing of LSD1 gene modulates histone methylation and acetylation and induces the apoptosis of JeKo-1 and MOLT-4 cells.Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.GATA2 regulates GATA1 expression through LSD1-mediated histone modification.Hematopoietic transcription factors and differential cofactor binding regulate PRKACB isoform expression.Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets.LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis.KDM1A microenvironment, its oncogenic potential, and therapeutic significance.
P2860
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P2860
Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@ast
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@en
type
label
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@ast
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@en
prefLabel
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@ast
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@en
P2093
P2860
P356
P1433
P1476
Dynamic interaction between TA ...... atopoiesis and leukemogenesis.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2012.8
P407
P577
2012-02-06T00:00:00Z