Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint - Wikidata - wikimedia - TriplyDB

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint

http://www.wikidata.org/entity/Q36438748

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Managing Single-Stranded DNA during Replication Stress in Fission Yeast Rescuing stalled or damaged replication forks Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast.Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design Fission yeast Rad52 phosphorylation restrains error prone recombination pathways The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast.Regulation of homologous recombination in eukaryotes.Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Recovery of arrested replication forks by homologous recombination is error-prone.Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.Targeting lung cancer through inhibition of checkpoint kinases.Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4.RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.The S-phase checkpoint: targeting the replication fork.The Intra-S Checkpoint Responses to DNA Damage.Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Homologous recombination as a replication fork escort: fork-protection and recovery.Replication fork reversal in eukaryotes: from dead end to dynamic response.Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex.Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover Cleavage of a model DNA replication fork by a Type I restriction endonuclease.Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.

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Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint

http://www.wikidata.org/entity/Q36438748

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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Cleavage of stalled forks by f ...... of DNA replication checkpoint

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Cleavage of stalled forks by f ...... of DNA replication checkpoint

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MBC.E07-07-0728

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Molecular Biology of the Cell

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Cleavage of stalled forks by f ...... of DNA replication checkpoint

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Benoît Froget

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Giuseppe Baldacci

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Joël Blaisonneau

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P2860

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae

Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

Mrc1 transduces signals of DNA replication stress to activate Rad53.

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

Characterization of homologous recombination induced by replication inhibition in mammalian cells

Regulation of replication timing in fission yeast.

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445-456

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10.1091/MBC.E07-07-0728

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2

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19

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2007-11-21T00:00:00Z

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2230577

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