Sequestration of mutated alpha1-antitrypsin into inclusion bodies is a cell-protective mechanism to maintain endoplasmic reticulum function.
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SERPINA2 is a novel gene with a divergent function from SERPINA1Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpinsAlpha-1-antitrypsin deficiencyNew Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms.Role of autophagy in suppression of inflammation and cancer.Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone.Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis.Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system.Autophagy in tumor suppression and cancer therapy.Activating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells.The emerging importance of autophagy in pulmonary diseases.The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse modelThe endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.Sustained HSP25 Expression Induces Clasmatodendrosis via ER Stress in the Rat Hippocampus.Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus.Autophagy: a critical regulator of cellular metabolism and homeostasis.Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagy.Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis.Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartmentAnomalous diffusion reports on the interaction of misfolded proteins with the quality control machinery in the endoplasmic reticulum.Disulfide bonding in neurodegenerative misfolding diseases.The unconventional secretion of ARMS2.
P2860
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P2860
Sequestration of mutated alpha1-antitrypsin into inclusion bodies is a cell-protective mechanism to maintain endoplasmic reticulum function.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年學術文章
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2007年學術文章
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2007年學術文章
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name
Sequestration of mutated alpha ...... ndoplasmic reticulum function.
@ast
Sequestration of mutated alpha ...... ndoplasmic reticulum function.
@en
type
label
Sequestration of mutated alpha ...... ndoplasmic reticulum function.
@ast
Sequestration of mutated alpha ...... ndoplasmic reticulum function.
@en
prefLabel
Sequestration of mutated alpha ...... ndoplasmic reticulum function.
@ast
Sequestration of mutated alpha ...... ndoplasmic reticulum function.
@en
P2093
P2860
P356
P1476
Sequestration of mutated alpha ...... endoplasmic reticulum function
@en
P2093
Brian Storrie
Giovanna Baldini
Giulia Baldini
Paola Narducci
Sameer Mohammad
Susana Granell
P2860
P304
P356
10.1091/MBC.E07-06-0587
P50
P577
2007-11-28T00:00:00Z