Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
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Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiencyFBG1 Is the Final Arbitrator of A1AT-Z DegradationDifferential expression of liver proteins between obesity-prone and obesity-resistant rats in response to a high-fat diet.A review of augmentation therapy for alpha-1 antitrypsin deficiency.Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomesActivating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells.Diagnosis and management of patients with α1-antitrypsin (A1AT) deficiency.Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency.Autophagy in hepatic fibrosis.Proteostasis strategies for restoring alpha1-antitrypsin deficiency.α(1)-antitrypsin deficiency and inflammation.Unravelling the twists and turns of the serpinopathies.Liver disease in alpha-1 antitrypsin deficiency: current understanding and future therapy.Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models.Advances in alpha-1-antitrypsin deficiency liver disease.Alpha-1 antitrypsin and liver disease: mechanisms of injury and novel interventions.Recent advancement of molecular mechanisms of liver fibrosis.Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradationRecent advances in understanding and treating COPD related to α1-antitrypsin deficiency.Activation of the c-Jun N-terminal kinase pathway aggravates proteotoxicity of hepatic mutant Z alpha1-antitrypsin.Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.Autophagy and gene therapy combine in the treatment of liver disease.Proteostasis: a new therapeutic paradigm for pulmonary disease.Pathophysiology of Alpha-1 Antitrypsin Deficiency Liver Disease.Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions.Down-regulation of hepatocyte nuclear factor-4α and defective zonation in livers expressing mutant Z α1-antitrypsin.α1-Antitrypsin deficiency.Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.Alpha-1 antitrypsin deficiency: outstanding questions and future directions.
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Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on June 2010
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Rapamycin reduces intrahepatic ...... liver injury in a mouse model
@en
Rapamycin reduces intrahepatic ...... liver injury in a mouse model.
@nl
type
label
Rapamycin reduces intrahepatic ...... liver injury in a mouse model
@en
Rapamycin reduces intrahepatic ...... liver injury in a mouse model.
@nl
prefLabel
Rapamycin reduces intrahepatic ...... liver injury in a mouse model
@en
Rapamycin reduces intrahepatic ...... liver injury in a mouse model.
@nl
P2093
P2860
P356
P1476
Rapamycin reduces intrahepatic ...... liver injury in a mouse model
@en
P2093
David Rudnick
Donna Halloran
Elizabeth M Brunt
Keith Blomenkamp
Mani Annamali
Shalesh Kaushal
P2860
P304
P356
10.1258/EBM.2010.009297
P577
2010-06-01T00:00:00Z