Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. - Wikidata - wikimedia - TriplyDB

Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development.

Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development.

http://www.wikidata.org/entity/Q36491749

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MAP'ing CNS development and cognition: an ERKsome process Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis Neurodevelopmental effects of insulin-like growth factor signaling.RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.Dystroglycan modulates the ability of insulin-like growth factor-1 to promote oligodendrocyte differentiation.Translational control of myelin basic protein expression by ERK2 MAP kinase regulates timely remyelination in the adult brain CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination.Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation.G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination.Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.Signaling mechanisms regulating myelination in the central nervous system.Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development."RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway.A-Raf: A new star of the family of raf kinases.Intracellular signaling pathway regulation of myelination and remyelination in the CNS.Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination.MEK Is a Key Regulator of Gliogenesis in the Developing Brain.Specific functions for ERK/MAPK signaling during PNS development.The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation.Knock-in(g) RAF for a loop.Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.The TAM receptor Tyro3 regulates myelination in the central nervous system.A proteomic approach to understand MMP-3-driven developmental processes in the postnatal cerebellum: Chaperonin CCT6A and MAP kinase as contributing factors.Molecular Diversity and Associated Phenotypic Spectrum of Germline CBL Mutations.Activation of CXCR7 receptor promotes oligodendroglial cell maturation.Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.

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Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development.

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Alcino Silva

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Dana Matzen

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Federica Catalanotti

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Gergana Galabova-Kovacs

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Gloria X Reyes

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Ingrid Walter

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Jürgen Zezula

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Ruth Herbst

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P2860

Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin

Endothelial apoptosis in Braf-deficient mice

Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia

Mutations of the BRAF gene in human cancer

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.

MEK kinase activity is not necessary for Raf-1 function.

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

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180

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Manuela Baccarini

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oligodendrocyte

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