Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory
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Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signallingAblation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellumB-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouseBRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.Ras and Rap signaling in synaptic plasticity and mental disorders.Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adultsRAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.Essential role of B-Raf in ERK activation during extraembryonic developmentSmall G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteinsNeurofibromin regulation of ERK signaling modulates GABA release and learning.Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytesBidirectional synaptic plasticity in the dentate gyrus of the awake freely behaving mouse.Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development.RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunctionL-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis.Modeling cognitive dysfunction in neurofibromatosis-1A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory.Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model.Protein profiles associated with context fear conditioning and their modulation by memantine.Molecular mechanisms underlying memory consolidation of taste information in the cortex.C-Raf is required for the initiation of lung cancer by K-Ras(G12D).Perturbed proteostasis in autism spectrum disorders.Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinomaPatient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.A Braf kinase-inactive mutant induces lung adenocarcinoma.Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway.
P2860
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P2860
Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory
description
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Januar 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/01/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/01/01)
@nl
наукова стаття, опублікована в січні 2006
@uk
مقالة علمية نشرت عام 2006 حول موضوع: دماغ
@ar
name
Forebrain-specific knockout of ...... ntiation, learning, and memory
@ast
Forebrain-specific knockout of ...... ntiation, learning, and memory
@en
Forebrain-specific knockout of ...... ntiation, learning, and memory
@nl
type
label
Forebrain-specific knockout of ...... ntiation, learning, and memory
@ast
Forebrain-specific knockout of ...... ntiation, learning, and memory
@en
Forebrain-specific knockout of ...... ntiation, learning, and memory
@nl
prefLabel
Forebrain-specific knockout of ...... ntiation, learning, and memory
@ast
Forebrain-specific knockout of ...... ntiation, learning, and memory
@en
Forebrain-specific knockout of ...... ntiation, learning, and memory
@nl
P2093
P2860
P3181
P356
P1476
Forebrain-specific knockout of ...... ntiation, learning, and memory
@en
P2093
Adele P Chen
K Peter Giese
Masuo Ohno
Rachel L Chen
P2860
P3181
P356
10.1002/JNR.20703
P577
2006-01-01T00:00:00Z