Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels - Wikidata - wikimedia - TriplyDB

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

http://www.wikidata.org/entity/Q36498394

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SOCE and cancer: Recent progress and new perspectives Phospholipase C signaling and calcium influx mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons.Store-operated calcium entry and diabetic complications Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3 TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells.STIMulating store-operated Ca(2+) entry.Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.Role of TRPC1 channel in skeletal muscle function.TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1 TRPC channels and their implication in neurological diseases Arachidonate-regulated Ca(2+) influx in human airway smooth muscle PAC1hop receptor activation facilitates catecholamine secretion selectively through 2-APB-sensitive Ca(2+) channels in PC12 cells Regulation of Ca2+ signaling with particular focus on mast cells.Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells.Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.Importance of Ca(2+) in gastric epithelial restitution-new views revealed by real-time in vivo measurements.The Orai-1 and STIM-1 complex controls human dendritic cell maturation Activation and regulation of store-operated calcium entry.Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.STIM and Orai: the long-awaited constituents of store-operated calcium entry Endothelin inhibits renin release from juxtaglomerular cells via endothelin receptors A and B via a transient receptor potential canonical-mediated pathway.Store-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells.The involvement of TRPC3 channels in sinoatrial arrhythmias Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype.STIM1-dependent store-operated Ca²⁺ entry is required for pathological cardiac hypertrophy.PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells.Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.Critical role for stromal interaction molecule 1 in cardiac hypertrophy Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease.Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes Lysophosphatidic acid promotes cell migration through STIM1- and Orai1-mediated Ca2+(i) mobilization and NFAT2 activation.

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Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

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2008 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Functional interactions among ...... model for SOCE/Icrac channels

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Christian Erxleben

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David L Armstrong

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Joel Abramowitz

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Lutz Birnbaumer

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Michael Xi Zhu

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Veit Flockerzi

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Yanhong Liao

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P2860

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry

trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry

Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein

Subunit composition of mammalian transient receptor potential channels in living cells

STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels

Functional interaction between InsP3 receptors and store-operated Htrp3 channels

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice

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10.1073/PNAS.0712288105

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105

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5565138

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18287061

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2268556

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