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A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

http://www.wikidata.org/entity/Q36499104

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Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations Mitochondrial DNA haplogroups influence AIDS progression Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine.Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond Tenofovir-associated bone density loss.The impact of perinatal HIV infection on older school-aged children's and adolescents' receptive language and word recognition skills Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition.In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue.Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy.Zidovudine and Lamivudine for HIV Infection.Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active antiretrovirals.Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorder Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection Mitochondrial toxicity studied with the PBMC of children from the Chinese national pediatric highly active antiretroviral therapy cohort.Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans Association of circulating cytochrome c with clinical manifestations of antiretroviral-induced toxicity Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue.Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1.WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F(1) Mice.Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs.Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors.Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study Mitochondria as a target of environmental toxicants.Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.Cytotoxicological analysis of a gp120 binding aptamer with cross-clade human immunodeficiency virus type 1 entry inhibition properties: comparison to conventional antiretrovirals Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy The roles of ethnicity and antiretrovirals in HIV-associated polyneuropathy: a pilot study Metabolic complications associated with antiretroviral therapy in HIV-infected and HIV-exposed uninfected paediatric patients.HIV-exposed uninfected children: a growing population with a vulnerable immune system?Pharmacokinetic considerations in the use of antivirals in neonates.

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P2860

A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

http://www.wikidata.org/entity/Q36499104

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2007 nî lūn-bûn

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A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

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A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

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A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

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William Lewis

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Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors.

Mitochondrial function in neurodegeneration and ageing.

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis.

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.

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