A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
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Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutationsMitochondrial DNA haplogroups influence AIDS progressionEvolutionary defined role of the mitochondrial DNA in fertility, disease and ageingLooking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approachTransplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine.Broad-spectrum agents for flaviviral infections: dengue, Zika and beyondTenofovir-associated bone density loss.The impact of perinatal HIV infection on older school-aged children's and adolescents' receptive language and word recognition skillsAntiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition.In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue.Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy.Zidovudine and Lamivudine for HIV Infection.Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active antiretrovirals.Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorderCerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infectionPharmacological considerations for tenofovir and emtricitabine to prevent HIV infectionMitochondrial toxicity studied with the PBMC of children from the Chinese national pediatric highly active antiretroviral therapy cohort.Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegansAssociation of circulating cytochrome c with clinical manifestations of antiretroviral-induced toxicityPolymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue.Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1.WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γEvaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F(1) Mice.Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs.Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors.Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot studyMitochondria as a target of environmental toxicants.Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.Cytotoxicological analysis of a gp120 binding aptamer with cross-clade human immunodeficiency virus type 1 entry inhibition properties: comparison to conventional antiretroviralsMitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapyThe roles of ethnicity and antiretrovirals in HIV-associated polyneuropathy: a pilot studyMetabolic complications associated with antiretroviral therapy in HIV-infected and HIV-exposed uninfected paediatric patients.HIV-exposed uninfected children: a growing population with a vulnerable immune system?Pharmacokinetic considerations in the use of antivirals in neonates.
P2860
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P2860
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@ast
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@en
type
label
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@ast
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@en
prefLabel
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@ast
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@en
P2860
P356
P1476
A brief overview of mechanisms of mitochondrial toxicity from NRTIs.
@en
P2093
James J Kohler
William Lewis
P2860
P304
P356
10.1002/EM.20223
P577
2007-04-01T00:00:00Z