Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. - Wikidata - wikimedia - TriplyDB

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.

http://www.wikidata.org/entity/Q38256335

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A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients.Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy WEE1 tyrosine kinase, a novel epigenetic modifier An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidates Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe.Functional analysis of the Aspergillus nidulans kinome.Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair Identification of Synergistic, Clinically Achievable, Combination Therapies for Osteosarcoma Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase.Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer.Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity Wee1 kinase as a target for cancer therapy.Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan.CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.Abrogating G₂/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.Replication fork dynamics and the DNA damage response.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.The essential kinase ATR: ensuring faithful duplication of a challenging genome.Expression and clinical significance of Wee1 in colorectal cancer.CLOCK regulates mammary epithelial cell growth and differentiation.SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.Control of Mus81 nuclease during the cell cycle.Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1.Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Cetuximab induces eme1-mediated DNA repair: a novel mechanism for cetuximab resistance.NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies Consequences of abnormal CDK activity in S phase.

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P2860

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.

http://www.wikidata.org/entity/Q38256335

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Wee1 controls genomic stabilit ...... g the Mus81-Eme1 endonuclease.

@en

type

label

Wee1 controls genomic stabilit ...... g the Mus81-Eme1 endonuclease.

@en

prefLabel

Wee1 controls genomic stabilit ...... g the Mus81-Eme1 endonuclease.

@en

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Journal of Cell Biology

P1476

Wee1 controls genomic stabilit ...... g the Mus81-Eme1 endonuclease.

@en

P2093

Marvin E Tanenbaum

http://www.w3.org/2001/XMLSchema#string

Michelle Debatisse

http://www.w3.org/2001/XMLSchema#string

Raimundo Freire

http://www.w3.org/2001/XMLSchema#string

Raquel Domínguez-Kelly

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Stephane Koundrioukoff

http://www.w3.org/2001/XMLSchema#string

Veronique A J Smits

http://www.w3.org/2001/XMLSchema#string

Yusé Martín

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

The DNA-damage response in human biology and disease

Megabase chromatin domains involved in DNA double-strand breaks in vivo

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

P304

567-579

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scholarly article

P356

10.1083/JCB.201101047

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P407

P433

4

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P478

194

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P50

René H. Medema

P577

2011-08-01T00:00:00Z

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P5875

51588611

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21859861

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3160579

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