The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
about
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.Misguided transcriptional elongation causes mixed lineage leukemiaTargeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technologyBinding cavities and druggability of intrinsically disordered proteins.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Therapeutic targeting of MLL.Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents.A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias.The molecular biology of mixed lineage leukemia.Molecular pathology of mixed-lineage leukemia.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Interference with RUNX1/ETO leukemogenic function by cell-penetrating peptides targeting the NHR2 oligomerization domain.
P2860
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P2860
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@ast
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@en
type
label
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@ast
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@en
prefLabel
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@ast
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@en
P2093
P2860
P1433
P1476
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
@en
P2093
Amanda C Winters
Cecily A Bennett
Charles S Hemenway
Christine M Palermo
P2860
P304
P356
10.1016/J.LEUKRES.2007.08.002
P577
2007-09-17T00:00:00Z