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A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expressionCovalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersEpimutational profile of hematologic malignancies as attractive target for new epigenetic therapiesTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyRare Cytogenetic Abnormalities and Alteration of microRNAs in Acute Myeloid Leukemia and Response to TherapyCancer epigenetics drug discovery and development: the challenge of hitting the markStructural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionPancreatic Cancer, A Mis-interpreter of the Epigenetic LanguageIn vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AMLThe leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasisHuman ALKBH4 interacts with proteins associated with transcriptionRegistered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemiaDiscovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation ApproachMenin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaPhase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Thyroid-like follicular carcinoma of the kidney: A report of two cases and literature review.Estimating developmental states of tumors and normal tissues using a linear time-ordered model.Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.Transcriptional regulation and its misregulation in disease.Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.Thyroid-like follicular carcinoma of the kidney with metastases to the lungs and retroperitoneal lymph nodesNon-muscle myosins in tumor progression, cancer cell invasion, and metastasis.Cancer genetics and epigenetics: two sides of the same coin?Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins.AF10 plays a key role in the survival of uncommitted hematopoietic cells.Development of five dual-color, double-fusion fluorescence in situ hybridization assays for the detection of common MLL translocation partnersMapping of MN1 sequences necessary for myeloid transformation.Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications.Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technologyWidely expressed Af17 is likely not required for embryogenesis, hematopoiesis, and animal survival.The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors.Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemiaNew insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.Viral-host interactions that control HIV-1 transcriptional elongation
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The molecular biology of mixed lineage leukemia.
@en
The molecular biology of mixed lineage leukemia.
@nl
type
label
The molecular biology of mixed lineage leukemia.
@en
The molecular biology of mixed lineage leukemia.
@nl
prefLabel
The molecular biology of mixed lineage leukemia.
@en
The molecular biology of mixed lineage leukemia.
@nl
P2860
P1433
P1476
The molecular biology of mixed lineage leukemia.
@en
P2093
Robert K Slany
P2860
P304
P356
10.3324/HAEMATOL.2008.002436
P577
2009-06-16T00:00:00Z