A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.
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Targeted therapies in sarcomas: challenging the challengeIntrinsically disordered proteins are potential drug targetsCatalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an updateThe biology of DHX9 and its potential as a therapeutic targetThe RNA helicase A in malignant transformationTwenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic LandscapesChildren's Oncology Group's 2013 blueprint for research: bone tumorsA small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft modelPrp43p contains a processive helicase structural architecture with a specific regulatory domainPotential approaches to the treatment of Ewing's sarcomaTargeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and TreatmentRecent advances in targeted therapy for Ewing sarcomaYK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasionFOXM1 is an oncogenic mediator in Ewing SarcomaLigand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteinsDevelopment of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imagingTargeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidinesStructures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.Notch inhibition as a promising new approach to cancer therapy.Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibitionNew strategies in ewing sarcoma: lost in translation?Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse modelEwing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesProteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzoneR1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axisAssemblages: functional units formed by cellular phase separationSmall-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.Targeted Therapy of Ewing's Sarcoma.Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitinationEwing sarcoma: an eponym window to history.The ETS family of oncogenic transcription factors in solid tumours.Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs
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P2860
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 05 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
@en
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
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type
label
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
@en
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
@nl
prefLabel
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
@en
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
@nl
P2093
P2860
P356
P1433
P1476
A small molecule blocking onco ...... its growth of Ewing's sarcoma.
@en
P2093
Aykut Uren
Hayriye V Erkizan
Jeffrey A Toretsky
Julie S Barber-Rotenberg
Linshan Yuan
Melinda Merchant
Milton L Brown
Ogan D Abaan
Silke Schlottmann
Sivanesan Dakshanamurthy
P2860
P2888
P304
P356
10.1038/NM.1983
P407
P577
2009-07-05T00:00:00Z
P5875
P6179
1021241680