A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. - Wikidata - wikimedia - TriplyDB

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.

http://www.wikidata.org/entity/Q37421771

about

Targeted therapies in sarcomas: challenging the challenge Intrinsically disordered proteins are potential drug targets Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update The biology of DHX9 and its potential as a therapeutic target The RNA helicase A in malignant transformation Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes Children's Oncology Group's 2013 blueprint for research: bone tumors A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model Prp43p contains a processive helicase structural architecture with a specific regulatory domain Potential approaches to the treatment of Ewing's sarcoma Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment Recent advances in targeted therapy for Ewing sarcoma YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion FOXM1 is an oncogenic mediator in Ewing Sarcoma Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.Notch inhibition as a promising new approach to cancer therapy.Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition New strategies in ewing sarcoma: lost in translation?Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis Assemblages: functional units formed by cellular phase separation Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.Targeted Therapy of Ewing's Sarcoma.Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination Ewing sarcoma: an eponym window to history.The ETS family of oncogenic transcription factors in solid tumours.Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs

P2860

Q21285014-CA6CFE31-6085-4F76-9185-2474FF17114B Q24633854-BFF9CDCA-7B65-47B7-B9AE-7856FA818F11 Q26747255-EC9B4AA5-8840-4014-9E12-CF55F1D611AC Q26749166-9C1931CF-55EB-4D64-87CB-506B461E34F8 Q26765181-98DAA7AF-E41F-44F5-BD57-5D18561C58A1 Q26782649-C9C0811D-3509-46C9-996E-DDEF7931F911 Q26801785-E295631A-DE93-4A90-A347-6639BE17073F Q27027664-D0007C8B-5C2A-4C8C-B289-3B2415DC2E92 Q27322372-CEED6A78-C453-4229-9F77-3D5F9C88A307 Q27662061-5CC0B820-8508-4DFE-8CE4-DC8470A9D6A1 Q28072744-F42FBFB1-4567-4B29-8F34-E66DB2FA4674 Q28076462-25023B55-FA94-4032-BCFA-DAA2524D0D7C Q28079316-534BA7B4-5F55-4E7D-9171-B07E6C6506D5 Q28477993-F01178AA-909D-4F08-BBA9-4AE6CFB39DF0 Q28485291-9B3EA8E4-D820-4BB8-8999-1FB31D9B70FB Q28534062-EFBB0ABD-10EA-4F64-BE17-B4CCA41A8406 Q28538391-97DD3C23-20BE-414F-BAA1-DCEB94FF2FF2 Q28771722-237063BE-1E1F-4749-915C-D24F0A66D256 Q30373611-23838016-5CA7-4D67-86A0-5DFA33ABFFEC Q30426785-87CCA4CD-CEE3-48B2-9830-E7DDE6C70B9C Q30427325-6AE8B32D-B927-471D-86FF-37C7539C48F2 Q33559559-AA3EE8FC-8B38-44C9-991F-3E151BF2E0EC Q33710833-BC581EB5-15C1-4C66-B44B-E4478A1F9CBC Q33750221-0BB4070A-9616-42F6-ACC2-BA6A916EA5F1 Q33758471-475ED102-121D-4AF4-8681-8AD6550AF863 Q33798299-62DA020F-1BEC-4061-9507-10DB241B0E27 Q33861072-81FDEF25-C17A-4648-84CA-C1A4DC619DED Q33907381-F73E16C4-6CB5-4B8B-A7E2-6AD2F28FD20B Q33909288-16E92CEC-73E0-4B31-8FB2-AE75A26C9F5E Q34011147-B4419F19-660D-4821-BDA9-15C6DFBD30B0 Q34021681-79CD5329-7B94-4970-B4DE-527BEA67EC6E Q34028538-7B68A743-103D-4D67-B6DF-FD02FE69DBD4 Q34055933-E3DA2CF8-CB32-4E61-B080-F1847DAADCEE Q34117231-2375F691-65CD-4714-A0F9-DA42A17B2EB1 Q34155816-5FB63C5B-F65A-4745-84C7-C1128D4D5E80 Q34262377-03CC5067-7BFD-467D-AEC8-C6C5A1666753 Q34285952-35AFA128-30E7-4091-B84D-E99C6BE48CCA Q34373047-2FA29A4F-78BE-42B3-99A5-D14857135F9B Q34555986-9EE6428D-C722-44B3-A37F-48E7E23F1878 Q34568434-2712B934-3D5C-4F5B-BF12-23654DC8259E

P2860

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.

http://www.wikidata.org/entity/Q37421771

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 05 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@en

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@nl

type

label

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@en

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@nl

prefLabel

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@en

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@nl

P1433

Q37421771-35AAD718-5A6E-4489-A13B-322FD2BC5C6F

P1476

Q37421771-DE97927C-A7F2-4353-8298-C977A90D021D

P2093

Q37421771-1144E07F-E67C-4D1F-B43A-A13B2EA42AAB

Q37421771-58C8BD3A-7FB6-4F08-AF8F-BF20392286D4

Q37421771-6972F49C-F842-47F8-B00B-4700B41494E0

Q37421771-77431241-1EAC-4987-8F36-CD302CF8D624

Q37421771-89FE46A0-14A9-4ABD-AC79-9AA80762913B

Q37421771-AFBEE5F8-BE13-43E3-8ECA-34D23751F1DC

Q37421771-B025D7FB-4EB4-4E2F-BBAA-5DBBFF109E97

Q37421771-B9C0AFBE-F8EE-4E84-9AE8-8C7713A39419

Q37421771-BDB88CBE-7606-45E4-9C86-A251EADCFD85

Q37421771-CF40A8C6-B9D1-4C82-8B71-2486C916AE05

P2860

Q37421771-034B2F15-CCD0-4CEB-B59B-650A96BB493D

Q37421771-14EF7430-C578-420A-8F2B-49342280A0A3

Q37421771-1905F12B-CD9C-490B-9804-AB0F7491BD62

Q37421771-22576D8C-1441-4A36-810C-0459756EBC0F

Q37421771-22E2047C-2D0F-423C-BCBD-4AB063A23B06

Q37421771-23BF8DDF-FC12-4473-A423-811451DBBEBE

Q37421771-2E354B64-4236-46BA-B2EF-C08301CC11EF

Q37421771-34739561-7FEE-499D-9A1C-89F234A33CF0

Q37421771-3BBEAA67-CBE5-4705-AA44-0B7828D0C63A

Q37421771-43BDC3DF-695D-4465-9EBC-FF453607A2AD

P2888

Q37421771-059CEB4B-B213-45EB-9715-7A47A5FDAAAE

P304

Q37421771-6B668F78-ED60-4FD3-8793-9141ADE3F9DA

P31

Q37421771-CD6AD33B-0616-474A-ACF2-C38B8128D2D1

P356

Q37421771-62C00EF4-5672-4A3A-9AEE-202E8777D72A

P407

Q37421771-3EA87D26-DFA8-4CB8-8084-CE42F9A66571

P433

Q37421771-7BAD421C-59BB-40D2-B268-DF94EC095DAC

P478

Q37421771-513B2DE8-8818-4DBC-A32D-D39601640C90

P577

Q37421771-14A99B06-8B01-44D3-B820-B7D426406ABF

P5875

Q37421771-AED95110-D997-4EB9-A0F7-E26ECF49BCCC

P6179

Q37421771-159725EC-095C-4E33-83A8-FDF589D361D9

P698

Q37421771-2136D487-9E41-4658-9760-69A3CF5DC545

P932

Q37421771-97297040-168D-49A9-9A2F-F23D28116BF3

P356

P1433

Nature Medicine

P1476

A small molecule blocking onco ...... its growth of Ewing's sarcoma.

@en

P2093

Aykut Uren

http://www.w3.org/2001/XMLSchema#string

Hayriye V Erkizan

http://www.w3.org/2001/XMLSchema#string

Jeffrey A Toretsky

http://www.w3.org/2001/XMLSchema#string

Julie S Barber-Rotenberg

http://www.w3.org/2001/XMLSchema#string

Linshan Yuan

http://www.w3.org/2001/XMLSchema#string

Melinda Merchant

http://www.w3.org/2001/XMLSchema#string

Milton L Brown

http://www.w3.org/2001/XMLSchema#string

Ogan D Abaan

http://www.w3.org/2001/XMLSchema#string

Silke Schlottmann

http://www.w3.org/2001/XMLSchema#string

Sivanesan Dakshanamurthy

http://www.w3.org/2001/XMLSchema#string

P2860

Control of apoptosis and mitotic spindle checkpoint by survivin

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

RNA helicase A is essential for normal gastrulation

The Amber biomolecular simulation programs

RNA helicase A mediates association of CBP with RNA polymerase II

Modeling of loops in protein structures

RNA helicase A interacts with RISC in human cells and functions in RISC loading.

RNA helicase A is necessary for translation of selected messenger RNAs.

P2888

P304

750-756

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM.1983

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

15

http://www.w3.org/2001/XMLSchema#string

P577

2009-07-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26654326

http://www.w3.org/2001/XMLSchema#string

P6179

1021241680

http://www.w3.org/2001/XMLSchema#string

P698

19584866

http://www.w3.org/2001/XMLSchema#string

P932

2777681

http://www.w3.org/2001/XMLSchema#string