Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. - Wikidata - wikimedia - TriplyDB

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

http://www.wikidata.org/entity/Q36512214

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Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1 A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway Role of p62/SQSTM1 in liver physiology and pathogenesis YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development.Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice Carboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation.Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.Alternative splicing in osteoclasts and Paget's disease of bone.SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination.The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.NIP45 negatively regulates RANK ligand induced osteoclast differentiation.WITHDRAWN: Cardamonin Inhibits Osteoclastogenesis Induced by Tumor Cells Through Interruption of the Signaling Pathway Activated by Receptor Activator of NF-κB Ligand.Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond.MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling.CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization.STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway NF-κB and cancer: a paradigm of Yin-Yang.Role of NF-κB in the skeleton Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of bone Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery Molecular genetic studies of gene identification for osteoporosis: the 2009 update TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget's Disease Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis.Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.TRAF molecules in cell signaling and in human diseases Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination.The role of T cells in osteoporosis, an update.Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes.NF-κB signaling and bone resorption.CYLD downregulation is correlated with tumor development in patients with hepatocellular carcinoma.

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P2860

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

http://www.wikidata.org/entity/Q36512214

description

2008 nî lūn-bûn

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2008年論文

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name

Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

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Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

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type

label

Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

@ast

Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

@en

prefLabel

Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

@ast

Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

@en

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Journal of Clinical Investigation

P1476

Deubiquitinating enzyme CYLD n ...... nd osteoclastogenesis in mice.

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P2093

Andrew J Lee

http://www.w3.org/2001/XMLSchema#string

Ato Wright

http://www.w3.org/2001/XMLSchema#string

Emmanuel M Paul

http://www.w3.org/2001/XMLSchema#string

Geetha Babu

http://www.w3.org/2001/XMLSchema#string

Jun You

http://www.w3.org/2001/XMLSchema#string

Mikyoung Chang

http://www.w3.org/2001/XMLSchema#string

Minying Zhang

http://www.w3.org/2001/XMLSchema#string

Shao-Cong Sun

http://www.w3.org/2001/XMLSchema#string

Wei Jin

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William Reiley

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P2860

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

IRAK-M is a negative regulator of Toll-like receptor signaling

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Identification of the familial cylindromatosis tumour-suppressor gene

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

Regulation and function of IKK and IKK-related kinases

A genomic and functional inventory of deubiquitinating enzymes

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

P304

1858-1866

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10.1172/JCI34257

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5

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P478

118

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5469461

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18382763

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2276399

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