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Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure

Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure

http://www.wikidata.org/entity/Q36512964

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Genomic and Proteomic Characterization of Acute Kidney Injury Applications of urinary proteomics in biomarker discovery Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI.Animal models of sepsis and sepsis-induced kidney injury Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid.Proteomics for biomarker discovery in acute kidney injury Identification of diagnostic urinary biomarkers for acute kidney injury Searching for mechanisms that matter in early septic acute kidney injury: an experimental study Chemical proteomics: terra incognita for novel drug target profiling.Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis Biomarkers of acute kidney injury.The Specific α1-Adrenergic Receptor Antagonist Prazosin Influences the Urine Proteome.Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury.Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats.Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury.Liver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.Protein biomarkers associated with acute renal failure and chronic kidney disease.The plasma proteome, adductome and idiosyncratic toxicity in toxicoproteomics research Meprin A metalloproteinase and its role in acute kidney injury.Novel opportunities for computational biology and sociology in drug discovery Urinary exosomal transcription factors, a new class of biomarkers for renal disease.The proteogenomic path towards biomarker discovery Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.Technology Insight: biomarker development in acute kidney injury--what can we anticipate?Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.Novel opportunities for computational biology and sociology in drug discovery.Recent progress in urinary proteomics.Proteomics-based investigations of animal models of disease.Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.The role of proteomics in understanding biological mechanisms of sepsis.Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway.Ischemic preconditioning attenuates lipid peroxidation and apoptosis in the cecal ligation and puncture model of sepsis.Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice.Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production Difference gel electrophoresis

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Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure

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Kidney International

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A N Schechter

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Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Efficacy and safety of recombinant human activated protein C for severe sepsis

Intensive insulin therapy in critically ill patients

The pathophysiology and treatment of sepsis

Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry.

Mechanisms of hydrazine toxicity in rat liver investigated by proteomics and multivariate data analysis.

Application of difference gel electrophoresis to the identification of inner medullary collecting duct proteins.

Early detection of cysteine rich protein 61 (CYR61, CCN1) in urine following renal ischemic reperfusion injury.

Cytokines and anticytokines in the pathogenesis of sepsis.

Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score.

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