Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress - Wikidata - wikimedia - TriplyDB

Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

http://www.wikidata.org/entity/Q36513505

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Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication Metnase promotes restart and repair of stalled and collapsed replication forks Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication A reduction of licensed origins reveals strain-specific replication dynamics in mice GammaH2AX and cancer Interactions of MCP1 with components of the replication machinery in mammalian cells.Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma.DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells.Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair CBX8, a novel DNA repair protein, promotes tumorigenesis in human esophageal carcinoma.More forks on the road to replication stress recovery Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines.Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.ATR phosphorylates SMARCAL1 to prevent replication fork collapse Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.How unfinished business from S-phase affects mitosis and beyond Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.The role of cyclin D1 in response to long-term exposure to ionizing radiation.The Intra-S Checkpoint Responses to DNA Damage.Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Substrate specificity of the MUS81-EME2 structure selective endonuclease.Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.Replication stalling and DNA microsatellite instability.Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts.Role of PCNA and RFC in promoting Mus81-complex activity.DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing.Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells.

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Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

http://www.wikidata.org/entity/Q36513505

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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name

Bloom's syndrome helicase and ...... onse to DNA replication stress

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Bloom's syndrome helicase and ...... onse to DNA replication stress

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Bloom's syndrome helicase and ...... onse to DNA replication stress

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Bloom's syndrome helicase and ...... onse to DNA replication stress

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Bloom's syndrome helicase and ...... onse to DNA replication stress

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Bloom's syndrome helicase and ...... onse to DNA replication stress

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J.JMB.2007.11.006

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Journal of Molecular Biology

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Bloom's syndrome helicase and ...... onse to DNA replication stress

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Kiyoshi Miyagawa

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Mari Katsura

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Melvenia M Martin

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Michael J Torres

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Mirit I Aladjem

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Tsutomu Shimura

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V Ashutosh Rao

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P2860

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

Regulation and localization of the Bloom syndrome protein in response to DNA damage

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells

A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication

Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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2007-11-13T00:00:00Z

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