Evidence that the 60-kDa protein of 17S U2 small nuclear ribonucleoprotein is immunologically and functionally related to the yeast PRP9 splicing factor and is required for the efficient formation of prespliceosomes.
about
Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivoCharacterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein familyHuman splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivoCUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motifPartial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assemblyThe 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesSMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome.Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formationSpecific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionCombined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNPThe yeast U2A'/U2B complex is required for pre-spliceosome formation.In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein.Interactions between highly conserved U2 small nuclear RNA structures and Prp5p, Prp9p, Prp11p, and Prp21p proteins are required to ensure integrity of the U2 small nuclear ribonucleoprotein in Saccharomyces cerevisiaeSnt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virusConserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.Multiple developmental requirements of noisette, the Drosophila homolog of the U2 snRNP-associated polypeptide SP3a60.The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomesInteraction domains and nuclear targeting signals in subunits of the U2 small nuclear ribonucleoprotein particle-associated splicing factor SF3a.ATP can be dispensable for prespliceosome formation in yeastThree recognition events at the branch-site adenine.Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract.Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assemblySequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs.Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.Association of the 72/74-kDa proteins, members of the heterogeneous nuclear ribonucleoprotein M group, with the pre-mRNA at early stages of spliceosome assembly.U2 small nuclear RNA is a substrate for the CCA-adding enzyme (tRNA nucleotidyltransferase).
P2860
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P2860
Evidence that the 60-kDa protein of 17S U2 small nuclear ribonucleoprotein is immunologically and functionally related to the yeast PRP9 splicing factor and is required for the efficient formation of prespliceosomes.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@ast
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@en
type
label
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@ast
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@en
prefLabel
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@ast
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@en
P2093
P2860
P356
P1476
Evidence that the 60-kDa prote ...... formation of prespliceosomes.
@en
P2093
F Galisson
R Lührmann
S E Behrens
P2860
P304
P356
10.1073/PNAS.90.17.8229
P407
P577
1993-09-01T00:00:00Z