The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP.
about
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodiesIdentification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosomeProteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.The network of protein-protein interactions within the human U4/U6.U5 tri-snRNPThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysisMolecular architecture of the human U4/U6.U5 tri-snRNPPrp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae.Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociationGenome-wide protein interaction screens reveal functional networks involving Sm-like proteinsThe Clf1p splicing factor promotes spliceosome assembly through N-terminal tetratricopeptide repeat contacts.The N-terminus of Prp1 (Prp6/U5-102 K) is essential for spliceosome activation in vivo.SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome.A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.Evidence that the 60-kDa protein of 17S U2 small nuclear ribonucleoprotein is immunologically and functionally related to the yeast PRP9 splicing factor and is required for the efficient formation of prespliceosomes.Competition between pre-mRNAs for the splicing machinery drives global regulation of splicing.Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis.Identification and characterization of Uss1p (Sdb23p): a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins.Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution.Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor.Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.The life of U6 small nuclear RNA, from cradle to grave.STABILIZED1, a stress-upregulated nuclear protein, is required for pre-mRNA splicing, mRNA turnover, and stress tolerance in Arabidopsis.
P2860
Q24292373-0AACEFBA-4EFF-40E5-9C79-C44886966447Q24299534-8D7B7952-5C9E-4E54-9763-B1D83E22883BQ24318331-5AF78328-2157-4EE4-AAB2-8EA3B77289ECQ24537200-9231E2B8-E87F-49BD-9D0E-85D3814A028DQ24548787-42071CB9-0AC9-4D5B-99D9-300474FAAE58Q27316447-E499454E-83A3-4E27-A003-10A38EF7B344Q27703519-B532857E-7255-4A3E-8539-237F307A0BCFQ27704181-8B3B0F36-D035-4B13-8368-B050136367B6Q27930533-50841419-BB06-4DB2-8E52-1C46CAA430ADQ27933924-E0B07B66-ADD3-4516-8384-F71B4468CAB8Q27938720-95F29B68-0E77-4C77-98E4-8DA276AED6D0Q27940003-5C58407E-8C7B-4B3A-A451-1F9FDADA6960Q33719434-B6C588F2-D4A5-45D5-ACB8-607408B926FFQ33944960-7F463F7D-0A55-443F-8A71-86E2E4F445ABQ35826664-FE645FC2-B09D-4546-BF7B-D84EB8872C13Q36518245-90834248-52F5-4861-A613-77ACBCAE31A2Q37166231-26960F6F-A6A8-4CFE-8C81-53FC2C3A410FQ37546093-7BF7B9F8-79B0-474E-B314-C160947232F2Q37696986-6D731BBF-57EB-4FE6-A147-BE3FA8D5F85FQ38584680-ED1CC695-2F82-46C5-8BE8-06AD0D389D23Q42035423-E598ED8F-40AF-46C7-8964-D609925E91CEQ43649668-68A8F9E8-CA81-4795-8EF0-D4E2AF0E1036Q48172115-39F1040D-C908-4DE7-BD5F-75296C91ABA8Q52016146-CD08C96F-827D-48F0-A3EA-24FE522761F6
P2860
The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP.
description
1993 nî lūn-bûn
@nan
1993 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@ast
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@en
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@nl
type
label
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@ast
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@en
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@nl
prefLabel
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@ast
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@en
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@nl
P2860
P356
P1476
The biochemical defects of prp ...... n of the [U4/U6.U5] tri-snRNP.
@en
P2093
P2860
P304
P356
10.1093/NAR/21.7.1555
P407
P577
1993-04-11T00:00:00Z