Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences
about
The concept of translocational regulationFine-tuning multiprotein complexes using small moleculesSelective inhibition of cotranslational translocation of vascular cell adhesion molecule 1Signal peptide-binding drug as a selective inhibitor of co-translational protein translocationRetrotranslocation of the chaperone calreticulin from the endoplasmic reticulum lumen to the cytosol.Yeast genes controlling responses to topogenic signals in a model transmembrane protein.Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.The efficiency of protein compartmentalization into the secretory pathway.Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.Cell type-specific neuroprotective activity of untranslocated prion protein.Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion proteinCotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.Conformational control through translocational regulation: a new view of secretory and membrane protein folding.Prion protein biosynthesis and its emerging role in neurodegeneration.Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex.The Potential effect of G915C polymorphism in regulating TGF-β1 transport into Endoplasmic Reticulum for cytokine production.The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.Substrate-specific function of the translocon-associated protein complex during translocation across the ER membraneLong-timescale dynamics and regulation of Sec-facilitated protein translocation.Neurotoxic species in prion disease: a role for PrP isoforms?Role of lysyl oxidase propeptide in secretion and enzyme activity.Protection from cytosolic prion protein toxicity by modulation of protein translocation.Controlling subcellular delivery to optimize therapeutic effectGenetic variations in toll-like receptors 7 and 8 modulate natural hepatitis C outcomes and liver disease progression.The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon.The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.Secretion of cartilage oligomeric matrix protein is affected by the signal peptide.Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue.Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine.Specific features of the prion protein transmembrane domain regulate nascent chain orientation.Signal sequences initiate the pathway of maturation in the endoplasmic reticulum lumen.A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection.US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal PeptideA Transmembrane Form of the Prion Protein Is Localized in the Golgi Apparatus of Neurons
P2860
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P2860
Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Substrate-specific regulation ...... by N-terminal signal sequences
@ast
Substrate-specific regulation ...... by N-terminal signal sequences
@en
type
label
Substrate-specific regulation ...... by N-terminal signal sequences
@ast
Substrate-specific regulation ...... by N-terminal signal sequences
@en
prefLabel
Substrate-specific regulation ...... by N-terminal signal sequences
@ast
Substrate-specific regulation ...... by N-terminal signal sequences
@en
P2860
P356
P1476
Substrate-specific regulation ...... by N-terminal signal sequences
@en
P2093
D T Rutkowski
V R Lingappa
P2860
P304
P356
10.1073/PNAS.141125098
P407
P577
2001-06-19T00:00:00Z