Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.
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IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemiaInterdiction of sphingolipid metabolism to improve standard cancer therapies.Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitizationTargeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidaseNovel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.Acid ceramidase as a therapeutic target in metastatic prostate cancer.Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.Sphingolipids function as downstream effectors of a fungal PAQR.Molecular targeting of acid ceramidase: implications to cancer therapy.Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapyCeramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.Fragment-Based Hologram QSAR Studies on a Series of 2,4-Dioxopyrimidine-1-Carboxamides As Highly Potent Inhibitors of Acid CeramidaseAutophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.Synthetic, non-natural analogs of ceramide elevate cellular ceramide, inducing apoptotic death to prostate cancer cells and eradicating tumors in mice.Synthesis and bioevaluation of omega-N-amino analogs of B13.Potent inhibition of Acid ceramidase by novel B-13 analogues.Cytotoxic activity and quantitative structure activity relationships of arylpropyl sulfonamides.Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression.
P2860
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P2860
Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@ast
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@en
type
label
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@ast
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@en
prefLabel
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@ast
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@en
P2093
P2860
P1476
Novel analogs of D-e-MAPP and ...... s potential anticancer agents.
@en
P2093
AiPing Bai
Alicja Bielawska
Jacek Bielawski
James S Norris
Nalini Mayroo
Zdzislaw M Szulc
P2860
P304
P356
10.1016/J.BMC.2007.08.033
P407
P577
2007-08-24T00:00:00Z